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β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
CTF18 interacts with replication protein A in response to replication stress
CTF18 interacts with replication protein A in response to replication stressopenaire
Protein-Priming of DNA Replication [PDF]
Annual Review of Biochemistry, 1991 Peer ...
Margarita Salas
exaly +4 more sources
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The Structure and Function of Replication Protein A in DNA Replication
2012In all organisms from bacteria and archaea to eukarya, single-stranded DNA binding proteins play an essential role in most, if not all, nuclear metabolism involving single-stranded DNA (ssDNA). Replication protein A (RPA), the major eukaryotic ssDNA binding protein, has two important roles in DNA metabolism: (1) in binding ssDNA to protect it and to ...
Aishwarya, Prakash +1 more
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The Mechanism of Adenovirus DNA Replication and the Characterization of Replication Proteins
1983The replication of the genome of human adenoviruses in permissive host cells is a highly efficient process. During the infection cycle a total amount of viral DNA is synthesized comparable to the entire chromosomal DNA content of the infected cell. In order to unravel the mechanism of adenovirus DNA replication this process has been studied in a number
J S, Sussenbach, P C, van der Vliet
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MCM proteins and DNA replication
Current Opinion in Cell Biology, 2006The MCM proteins identify a group of ten conserved factors functioning in the replication of the genomes of archae and eukaryotic organisms. Among these, MCM2-7 proteins are related to each other and form a family of DNA helicases implicated at the initiation step of DNA synthesis.
Maiorano, D., Lutzmann, M., Méchali, M.
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Journal of Molecular Biology, 1970
Abstract In Escherichia coli, DNA replication can occur in the absence of protein synthesis after a period of replication inhibition. Such replication will occur after thymine starvation, nalidixic acid treatment or exposure of a DNA temperature-sensitive mutant to a period at the non-permissive temperature.
T, Kogoma, K G, Lark
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Abstract In Escherichia coli, DNA replication can occur in the absence of protein synthesis after a period of replication inhibition. Such replication will occur after thymine starvation, nalidixic acid treatment or exposure of a DNA temperature-sensitive mutant to a period at the non-permissive temperature.
T, Kogoma, K G, Lark
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Interplay of replication checkpoints and repair proteins at stalled replication forks
DNA Repair, 2007DNA replication is an essential process that occurs in all growing cells and needs to be tightly regulated in order to preserve genetic integrity. Eukaryotic cells have developed multiple mechanisms to ensure the fidelity of replication and to coordinate the progression of replication forks.
D. Branzei, M. Foiani
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Adenovirus DNA Replication: Mechanism and Replication Proteins
1983The human adenoviruses, especially type 5 (Ad5) and type 2 (Ad2), can be easily cultivated in HeLa or KB cells. They have been a favorite subject for DNA replication studies in the eukaryotic cell during the last decade. The mature adenovirus genome isolated from virions consists of a linear duplex DNA molecule of about 35,000 base pairs.
Peter C. van der Vliet +3 more
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MCM Proteins in DNA Replication
Annual Review of Biochemistry, 1999▪ Abstract The MCM proteins are essential replication initiation factors originally identified as proteins required for minichromosome maintenance in Saccharomyces cerevisiae. The best known among them are a family of six structurally related proteins, MCM2–7, which are evolutionally conserved in all eukaryotes.
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