Results 81 to 90 of about 2,724,889 (347)

Modeling and replicating statistical topology and evidence for CMB nonhomogeneity [PDF]

Proceedings of the National Academy of Sciences, 2017
SignificanceUnder the general heading of “topological data analysis” (TDA), the recent adoption of topological methods for the analysis of large, complex, and high-dimensional data sets has established that the abstract concepts of algebraic topology provide powerful tools for data analysis. However, despite the successes of TDA, most applications have
Robert J. Adler, Sarit Agami, Pratyush Pranav   +2 more
openaire   +3 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Revisiting the Replication Crisis and the Untrustworthiness of Empirical Evidence

Stats
The current replication crisis relating to the non-replicability and the untrustworthiness of published empirical evidence is often viewed through the lens of the Positive Predictive Value (PPV) in the context of the Medical Diagnostic Screening (MDS ...
Aris Spanos
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Replication or exploration? Sequential design for stochastic simulation experiments

, 2019
We investigate the merits of replication, and provide methods for optimal design (including replicates), with the goal of obtaining globally accurate emulation of noisy computer simulation experiments.
Binois, Mickael, Gramacy, Robert B, Huang, Jiangeng, Ludkovski, Mike   +3 more
core   +2 more sources

ViralPlaque: a Fiji macro for automated assessment of viral plaque statistics

PeerJ, 2019
Plaque assay has been used for a long time to determine infectious titers and characterize prokaryotic and eukaryotic viruses forming plaques. Indeed, plaque morphology and dimensions can provide information regarding the replication kinetics and the ...
Marco Cacciabue, Anabella Currá, M. Gismondi   +2 more
semanticscholar   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Rank Statistics in Biological Evolution

, 2005
We present a statistical analysis of biological evolution processes. Specifically, we study the stochastic replication-mutation-death model where the population of a species may grow or shrink by birth or death, respectively, and additionally, mutations ...
, Ben-Naim E Krapivsky P L, Durbin R, Durrett R Schweisenberg J, E Ben-Naim, Ewens W J, Felsenstein J, Gould S J, Harris T E, Horton R E, Huynen M A, John Sepkoski J, Knuth D E, P L Krapivsky, Page R D M, Simon H A, Tudge C, Waterman M S, Yule G U   +18 more
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

“Cake causes herpes?” - promiscuous dichotomisation induces false positives

BMC Medical Research Methodology
Background Continuous biomedical data is often dichotomized into two or more groups for analysis, despite long-standing warnings from statisticians that this constitutes bad practice.
David Robert Grimes, James Heathers
doaj   +1 more source