Results 101 to 110 of about 34,336 (231)

CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold

eLife, 2020
The eukaryotic replisome assembles around the CMG helicase, which stably associates with DNA replication forks throughout elongation. When replication terminates, CMG is ubiquitylated on its Mcm7 subunit and disassembled by the Cdc48/p97 ATPase.
T. Deegan, Pragya P Mukherjee, R. Fujisawa, Cristian Polo Rivera, K. Labib   +4 more
semanticscholar   +1 more source

Humeroradial Synostosis: An Updated Classification and Differential Diagnosis Based on Genetic Aetiology

Clinical Genetics, Volume 108, Issue 4, Page 379-392, October 2025.
The proposed updated classification of humeroradial synostosis is based on the molecular pathways of the genes involved: (1) chondrogenesis and osteogenesis; (2) limb development and patterning; (3) genome regulation. Thus, pathologies belonging to the same molecular type may have overlapping clinical phenotypes, helping to structure the diagnostic ...
Fiona Leduc, Clémence Vanlerberghe, Fabienne Escande, Perrine Brunelle, Florence Petit, Anne Dieux   +5 more
wiley   +1 more source

Reversal of DDK-mediated MCM phosphorylation by Rif1-PP1 regulates replication initiation and replisome stability independently of ATR/Chk1 [PDF]

, 2017
Dbf4-dependent kinases (DDKs) are required for the initiation of DNA replication, their essential targets being the MCM2-7 proteins. We show that, in Xenopus laevis egg extracts and human cells, hyper-phosphorylation of DNA-bound Mcm4, but not ...
Alver, Robert C., Blow, J. Julian, Chadha, Gaganmeet Singh, Gillespie, Peter J.   +3 more
core   +10 more sources

Evaluation of DNA primase DnaG as a potential target for antibiotics [PDF]

, 2014
Mycobacteria contain genes for several DNA-dependent RNA primases, including dnaG, which encodes an essential replication enzyme that has been proposed as a target for antituberculosis compounds.
Aidan Doherty, Aneta Kuron, Anna Brzostek, Aravind, Bartlett, Biswas, Bozena Dziadek, Brzostek, Centers for Disease Control and Prevention, Chauhan, Ciarrocchi, Collins, Corn, Della, Draper, Dwivedi, Dye, Dziadek, Frick, Gengenbacher, Griep, Iyer, Jaroslaw Dziadek, Klann, Korycka-Machala, Kuchta, Lao-Sirieix, Lao-Sirieix, Lehman, Livak, Malgorzata Korycka-Machala, Marcin Nowosielski, Modrich, Parish, Pawelczyk, Pitcher, Pitcher, Pitcher, Raviglione, Sambrook, Snapper, Srivastava, Swart, Trias, Velayati, Weller, Weller, Zhang   +47 more
core   +1 more source

Bypass of complex co-directional replication-transcription collisions by replisome skipping

Nucleic Acids Research, 2021
Collisions between the replisome and RNA polymerases [RNAP(s)] are the main obstacle to DNA replication. These collisions can occur either head-on or co-directionally with respect to the direction of translocation of both complexes.
Jan-Gert Brüning, K. Marians
semanticscholar   +1 more source

Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2

Cell Reports, 2019
Summary: Eukaryotic replisomes are driven by the mini chromosome maintenance (MCM [M]) helicase complex, an offset ring locked around the template for leading strand synthesis by CDC45 (C) and GINS (G) proteins.
Jing Huang, Jing Zhang, Marina A. Bellani, Durga Pokharel, Julia Gichimu, Ryan C. James, Himabindu Gali, Chen Ling, Zhijiang Yan, Dongyi Xu, Junjie Chen, Amom Ruhikanta Meetei, Lei Li, Weidong Wang, Michael M. Seidman   +14 more
doaj   +1 more source

Mutations that Separate the Functions of the Proofreading Subunit of the Escherichia coli Replicase

, 2015
The dnaQ gene of Escherichia coli encodes the Ɛ subunit of DNA polymerase III, which provides the 3\u27 - 5\u27 exonuclease proofreading activity of the replicative polymerase.
Kreuzer, Kenneth N., Whatley, Zakiya
core   +1 more source

Manipulating Replisome Dynamics to Enhance Lambda Red-Mediated Multiplex Genome Engineering [PDF]

, 2013
Disrupting the interaction between primase and helicase in Escherichia coli increases Okazaki fragment (OF) length due to less frequent primer synthesis.
Church, George McDonald, Gregg, Christopher, Lajoie, Marc Joseph, Mosberg, Joshua Adam Weintrob, Washington, G. C.   +4 more
core   +1 more source

Single-molecule characterization of SV40 replisome and novel factors: human FPC and Mcm10

Nucleic Acids Research
The simian virus 40 (SV40) replisome only encodes for its helicase; large T-antigen (L-Tag), while relying on the host for the remaining proteins, making it an intriguing model system.
Yujing Ouyang, Amani M. Al-Amodi, M. Tehseen, Lubna Alhudhali, Afnan Shirbini, Masateru Takahashi, Vlad-Stefan Raducanu, Gang Yi, A. U. Danazumi, A. De Biasio, Samir M. Hamdan   +10 more
semanticscholar   +1 more source

Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage

Advanced Science, Volume 12, Issue 35, September 18, 2025.
The oncogenic ETS factor ETV4 exerts a pleiotropic control over DNA replication both in a transcription‐dependent and ‐independent fashion in NSCLC cells. High‐ETV4 expression leads to R‐loop formation and DNA damage in response to TOP1 inhibition.
Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M. Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing   +14 more
wiley   +1 more source