Results 51 to 60 of about 100,632 (325)

Possible predicative role of electrical risk score on transcatheter aortic valve replacement outcomes in older patients. preliminary data [PDF]

, 2018
Background:Transcatheter aortic valve replacement (TAVR) is an effective procedure capable to change the natural history of the degenerative aortic valve stenosis.
DI IORIO, Claudia, Fabietti, Marcella, Magri', Damiano, Mancone, Massimo, Mariani, MARCO VALERIO, Mastropietri, Fabiola, Moscucci, Federica, Parrotta, Ilaria, Piccirillo, Gianfranco, Sardella, Gennaro   +9 more
core   +1 more source

Repolarization Alternans [PDF]

Circulation Research, 2000
The appearance of electrocardiographic T-wave alternans with elevated heart rate or metabolic insult has been observed for nearly a century.1 Macroscopic T-wave alternans is often noted as a harbinger of sudden arrhythmic death.2 Efforts to quantify the magnitude of more subtle repolarization alternans and relate these measurements to arrhythmia ...
openaire   +1 more source

Mechanically Induced Ectopy via Stretch-Activated Cation-Nonselective Channels Is Caused by Local Tissue Deformation and Results in Ventricular Fibrillation if Triggered on the Repolarization Wave Edge (Commotio Cordis)

Circulation: Arrhythmia and Electrophysiology, 2017
Background— External chest impacts (commotio cordis) can cause mechanically induced premature ventricular excitation (PVEM) and, rarely, ventricular fibrillation (VF).
T. Quinn, Honghua Jin, Peter Lee, P. Kohl   +3 more
semanticscholar   +1 more source

Electrocardiographic manifestation of cardiac repolarization dispersion [PDF]

, 2019
Alterations of repolarization heterogeneity in the heart have been established as anAlterations of repolarization heterogeneity in the heart have been established as ...
Sedova Ksenia
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The role of M cells and the long QT syndrome in cardiac arrhythmias: simulation studies of reentrant excitations using a detailed electrophysiological model

, 2004
In this numerical study, we investigate the role of intrinsic heterogeneities of cardiac tissue due to M cells in the generation and maintenance of reentrant excitations using the detailed Luo-Rudy dynamic model. This model has been extended to include a
Cherry E. M., Diego J. M. D., Hervé Henry, Wouter-Jan Rappel   +3 more
core   +1 more source

Enhancement of K+ conductance improves in vitro the contraction force of skeletal muscle in hypokalemic periodic paralysis [PDF]

, 1990
An abnormal ratio between Na+ and K+ conductances seems to be the cause for the depolarization and paralysis of skeletal muscle in primary hypokalemic periodic paralysis.
Ballanyi, Beam, Bretag, Cook, Engel, Escande, Fosset, Hamilton, Huang, Iaizzo, Lehmann-Horn, Quasthoff, Ruff, Ruff, R�del, R�del, Sanguinetti, Spuler, Sturgess, Tanabe   +19 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Contribution of Depolarization and Repolarization Changes to J-Wave Generation and Ventricular Fibrillation in Ischemia

Frontiers in Physiology, 2020
Background: Activation delay in ischemic myocardium has been found to contribute to J-wave appearance and to predict ventricular fibrillation (VF) in experimental myocardial infarction.
Alena S. Tsvetkova, Jan E. Azarov, Jan E. Azarov, Jan E. Azarov, Olesya G. Bernikova, Alexey O. Ovechkin, Alexey O. Ovechkin, Marina A. Vaykshnorayte, Marina M. Demidova, Marina M. Demidova, Pyotr G. Platonov, Pyotr G. Platonov   +11 more
doaj   +1 more source

Computational probabilistic quantification of pro-arrhythmic risk from scar and left-to-right heterogeneity in the human ventricles [PDF]

, 2013
Both scar and left-to-right ventricular (LV/RV) differences in repolarization properties have been implicated as risk factors for lethal arrhythmias.
Bueno-Orovio, A., Rodriguez, B., Wallman, M.   +2 more
core   +1 more source