Results 51 to 60 of about 1,271,120 (303)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Rhythm in the speech of a person with right hemisphere damage: Applying the pairwise variability index [PDF]

, 2007
Although several aspects of prosody have been studied in speakers with right hemisphere damage (RHD), rhythm remains largely uninvestigated. This study compares the rhythm of an Australian English speaker with right hemisphere damage (due to a stroke ...
Abercrombie D, Ackermann H., Behrens S. J, Charcot J, Crystal D, Dankovičová J., Dauer R. M, Edmunds L. A., Fischer-Jørgensen E., Fletcher J., Gay T, Grabe E., Halliday M. A. K, Horvath B. M, Kent R. D., Low E. L., Monrad-Krohn G. H, Monrad-Krohn G. H, Peterson G. E., Pike K. L, Ramus F., Raven J. C, Roach P, Roach P, Ross E. D, Smith A, Trask R. L, Wechsler D, Wells J. C, White L., Whitworth N   +30 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Vozes em embate na mídia de informação e produção da objetividade: polêmicas em torno da precarização do trabalho na escola Voices in struggle in information media discourses and the production of objectivity: on precarization of work in school

DELTA: Documentação de Estudos em Lingüística Teórica e Aplicada, 2011
Neste artigo, procedemos à análise de modos de produção de sentidos sobre o trabalho dos profissionais de Educação do ensino médio na mídia impressa, a partir de uma perspectiva enunciativa.
Bruno Deusdará, Décio Rocha
doaj   +1 more source

Perceived Stigmatization of Children with Speech-Language Impairment and Their Parents [PDF]

, 2008
Objective: Developmental disorders in childhood are generally assumed to have stigmatizing effects. The goal of the present study was to assess whether parents of children with speech-language impairment perceive stigmatization of their child or ...
Macharey, Georg, Suchodoletz, Waldemar von   +1 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Discours direct : syntaxe et prosodie

E-REA, 2015
This paper investigates the intonational phrasing of reporting clauses. It is based on the acoustic analysis of an oral corpus drawn from the radio (BBC Radio for British English and National Public Radio for American English) which has been compiled at ...
Sylvie HANOTE
doaj   +1 more source

A cleft care workshop for speech and language pathologists in resource-limited countries : the participants' experiences about cleft care in Uganda and satisfaction with the training effect [PDF]

, 2020
Objectives: workshops and specialized training programs are often inaccessible for speech and language pathologists (SLPs) based in resource-limited countries given the lack of supply, the long travel distances and the excessive participation fees.
Alighieri, Cassandra, Bettens, Kim, Bruneel, Laura, D'haeseleer, Evelien, Kissel, Imke, Pype, Peter, Sseremba, Daniel, Van Lierde, Kristiane   +7 more
core   +2 more sources

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Le discours rapporté dans un corpus d’anglais oral : formes et frontières

E-REA, 2019
This paper investigates the intonational phrasing of reported speech clauses. It is based on the acoustic analysis of an oral corpus drawn from the radio (BBC Radio for British English and National Public Radio for American English) which has been ...
Sylvie HANOTE
doaj   +1 more source