Results 201 to 210 of about 7,567,038 (395)

Improving Reporter Gene Assay Methodology for Evaluating the Ability of Compounds to Restore P53 Activity. [PDF]

Int J Mol Sci, 2022
Han X, Du J, Shi D, Li L, Li D, Zhang K, Lin S, Zhu J, Huang Z, Zhou Y, Fang Z.   +10 more
europepmc   +1 more source

Dual reporter genes enabling cell tracing with viable and reliable selection of various cell types [PDF]

, 2006
C. N. Hwang, Seong Su Hong, S. S. Choi, K. S. Lee, S. S. Park, Sangyun Lee   +5 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials. [PDF]

Front Toxicol, 2022
Martin S, de Haan L, Miro Estruch I, Eder KM, Marzi A, Schnekenburger J, Blosi M, Costa A, Antonello G, Bergamaschi E, Riganti C, Beal D, Carrière M, Taché O, Hutchison G, Malone E, Young L, Campagnolo L, La Civita F, Pietroiusti A, Devineau S, Baeza A, Boland S, Zong C, Ichihara G, Fadeel B, Bouwmeester H.   +26 more
europepmc   +1 more source

Figure S5 from PET Reporter Gene Imaging and Ganciclovir-Mediated Ablation of Chimeric Antigen Receptor T Cells in Solid Tumors

, 2023
Surya Murty, Louai Labanieh, Tara Murty, Gayatri Gowrishankar, Tom Haywood, Israt S. Alam, Corinne Beinat, Elise Robinson, Amin Aalipour, Dorota D. Klysz, Jennifer R. Cochran, Robbie G. Majzner, Crystal L. Mackall, Sanjiv S. Gambhir   +13 more
openalex   +1 more source

3D chromatin structure and massively parallel reporter assays in hiPSC‐derived microglia and human macrophages identifies novel putative Alzheimer’s Disease risk genes [PDF]

, 2023
Ivana Yoseli Quiroga, Marielle L. Bond, Susan D’Costa, Jessica Bell, Jessica C. McAfee, Kathleen S Metz Reed, Isha R Sahasrabudhe, Mary Patrucco, Hyejung Won, Douglas H. Phanstiel   +9 more
openalex   +1 more source

Evaluating the microRNA targeting sites by luciferase reporter gene assay.

Methods in molecular biology, 2013
Yi Jin, Zujian Chen, Xiqiang Liu, Xiaofeng Zhou   +3 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Reporter gene assays and chromatin-level assays define substantially non-overlapping sets of enhancer sequences. [PDF]

BMC Genomics, 2023
Lindhorst D, Halfon MS.
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source