Results 241 to 250 of about 7,873,006 (309)

A promoter::luciferase reporter gene imaging toolkit in Kalanchoë laxiflora reveals molecular elements responsible for the circadian regulation of Crassulacean acid metabolism (CAM)

Pritchard JH, Waller JL, Gould PJD, Kadu N, Boxall SF, Dever LV, Kneřová J, O’Maoileidigh D, Hartwell J.   +8 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

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Reporter Gene Imaging

American Journal of Roentgenology, 2013
The purposes of this article are to summarize the basic concept and the strategies of reporter imaging; introduce reporter genes frequently used in optical imaging, nuclear medicine, and MRI for in vivo application; and show typical examples of reporter gene imaging.In molecular biology, many reporter genes have been developed for monitoring cellular ...
Hyewon Youn
exaly   +4 more sources

Reporter Gene Vectors and Assays

Molecular Biotechnology, 1999
Gene reporter systems play a key role in gene expression and regulation studies. This review describes the ideal reporter systems, including reporter expression vector design. It summarizes the many uses of genetic reporters and outlines the currently available and commonly used reporter systems.
E, Schenborn, D, Groskreutz
exaly   +3 more sources

Luciferases as Reporter Genes

2006
Luciferase is the ideal reporter gene to provide temporal and spatial information on promoter activity in Arabidopsis and other eukaryotes; the noninvasive detection of luminescence and short half-life of luciferase activity allow repeated measurements of individual seedlings over several days to assay dynamic changes in gene expression.
Megan M, Southern, Paul E, Brown, Anthony, Hall   +2 more
openaire   +2 more sources

Reporter gene expression for monitoring gene transfer

Current Opinion in Biotechnology, 1997
The use of reporters such as green fluorescent protein (GFP) and firefly luciferase permit highly sensitive and nondestructive monitoring of gene transfer and expression. Modifications in GFP which increase intensity and thermostability, as well as alter its spectral qualities, have facilitated the use of GFP in a variety of gene transfer methods ...
S, Welsh, S A, Kay
openaire   +2 more sources

Monitoring gene therapy with reporter gene imaging

Seminars in Nuclear Medicine, 2001
Rapid advances in imaging technologies and gene transfer strategies offer a great opportunity to optimize clinical trials of human gene therapy. Reporter genes are emerging as very powerful tools to monitor the delivery, magnitude, and time variation of therapeutic gene transfer in vivo.
P, Ray, E, Bauer, M, Iyer, J R, Barrio, N, Satyamurthy, M E, Phelps, H R, Herschman, S S, Gambhir   +7 more
openaire   +2 more sources

A Reporter Gene to Analyse the Hypermutation of Immunoglobulin Genes

Journal of Molecular Biology, 1995
The affinity maturation of antibodies is driven by somatic hypermutation which is localized to specific segments of the coding genes. The information available on this process derives from studies in vivo. With the intention of developing new approaches, we have constructed a fusion gene between a kappa chain and a selectable neomycin resistance gene ...
Y L, Chui, F, Lozano, J M, Jarvis, R, Pannell, C, Milstein   +4 more
openaire   +2 more sources

Aequorin as a Reporter Gene

2006
Reporter proteins allow one to monitor cellular parameters that are involved in signal transduction, development, metabolic processes, and transport. There are targeting strategies available to direct the indicator protein exactly to the locale inside the organism from which information is desired.
openaire   +2 more sources

Genes and Development—A Workshop Report

Placenta, 2004
The ‘Genes and Development’ workshop focused on recentadvances in our understanding of the molecular control ofplacental development, focusing on the mouse model. JayCross gave an introduction to mouse placental developmentthat outlined the major structures and cell types. He alsoreviewed the considerable progress that has been made indefining molecular
J C, Cross, P M, Coan, R, Fundele, M, Hemberger, M, Kibschull, A, Ferguson-Smith   +5 more
openaire   +2 more sources