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Reporter genes in transgenic mice
Transgenic Research, 1994Although in vivo models utilizing endogenous reporter genes have been exploited for many years, the use of reporter transgenes to dissect biological issues in transgenic animals has been a relatively recent development. These transgenes are often, but not always, of prokaryotic origin and encode products not normally associated with eukaryotic cells ...
C, Cui +4 more
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Tetracysteine as a Reporter for Gene Therapy
Biomedical and Environmental Sciences, 2009To study the feasibility of using tetracysteine (TC) reporter in gene therapy.Effects of TC reporter and conventional reporter genes encoding green fluorescence protein (GFP) and luciferase (Luc) on expression and function of the therapeutic gene MGMT(P140K) were compared. Cytotoxicity and drug resistance were studied by Western blot.
Xu, Chen-Yu +6 more
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2010
In recent years, several reporter genes have been developed that can serve as a beacon for non-invasive magnetic resonance imaging (MRI). Here, we provide a brief summary of recent advances in MRI reporter gene technology, as well as detailed "hands-on" protocols for cloning, expression, and imaging of reporter genes based on chemical exchange ...
Guanshu, Liu +2 more
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In recent years, several reporter genes have been developed that can serve as a beacon for non-invasive magnetic resonance imaging (MRI). Here, we provide a brief summary of recent advances in MRI reporter gene technology, as well as detailed "hands-on" protocols for cloning, expression, and imaging of reporter genes based on chemical exchange ...
Guanshu, Liu +2 more
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Reporter Gene Assays in Ecotoxicology
2016The need for simple and rapid means for evaluating the potential toxic effects of environmental samples has prompted the development of reporter gene assays, based on tester cells (bioreporters) genetically engineered to report on sample toxicity by producing a readily quantifiable signal. Bacteria are especially suitable to serve as bioreporters owing
Tal, Elad, Shimshon, Belkin
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Radionuclide reporter gene imaging for cardiac gene therapy
European Journal of Nuclear Medicine and Molecular Imaging, 2007In the field of cardiac gene therapy, angiogenic gene therapy has been most extensively investigated. The first clinical trial of cardiac angiogenic gene therapy was reported in 1998, and at the peak, more than 20 clinical trial protocols were under evaluation.
Masayuki, Inubushi, Nagara, Tamaki
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Gene manipulation success reported
Nursing Standard, 1990For the first time foreign genes have been inserted into the human body.
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Radionuclide Gene and Reporter Gene Imaging
2019In the 1970s, the Johns Hopkins University School of Medicine (JHUSOM) and Harvard Medical School discovered that antisense oligonucleotides (ASON) could actually block the expression of specific genes. Since then, a new genetic engineering technology—antisense technology—has emerged.
Xiaoli Lan +3 more
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Nature, 1989
The GUS reporter gene system is already a powerful tool for the assessment of gene activity in transgenic plants. Further developments may lead to routine in vivo analysis and fusion genetics.
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The GUS reporter gene system is already a powerful tool for the assessment of gene activity in transgenic plants. Further developments may lead to routine in vivo analysis and fusion genetics.
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1994
The principle of using reporter genes in studying molecular processes in a living cell means that in the natural gene, a synthetic modification is introduced (or the protein coding sequence is deleted and replaced by another gene) in order either to simplify the detection of the gene product or to distinguish it from similar or identical genes in the ...
Luis Herrera-Estrella +3 more
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The principle of using reporter genes in studying molecular processes in a living cell means that in the natural gene, a synthetic modification is introduced (or the protein coding sequence is deleted and replaced by another gene) in order either to simplify the detection of the gene product or to distinguish it from similar or identical genes in the ...
Luis Herrera-Estrella +3 more
openaire +1 more source