Results 61 to 70 of about 7,873,006 (309)

Engineering recombinant replication-competent bluetongue viruses expressing reporter genes for in vitro and non-invasive in vivo studies

Microbiology Spectrum
Bluetongue virus (BTV) is the causative agent of the important livestock disease bluetongue (BT), which is transmitted via Culicoides bites. BT causes severe economic losses associated with its considerable impact on health and trade of animals.
Sergio Utrilla-Trigo, Luis Jiménez-Cabello, Alejandro Marín-López, Miguel Illescas-Amo, Germán Andrés, Eva Calvo-Pinilla, Gema Lorenzo, Piet A. van Rijn, Javier Ortego, Aitor Nogales   +9 more
doaj   +1 more source

Indexing TNF-α gene expression using a gene-targeted reporter cell line

BMC Biology, 2009
Background Current cell-based drug screening technologies utilize randomly integrated reporter genes to index transcriptional activity of an endogenous gene of interest.
Engelhardt John F, Lei-Butters Diana, Yan Ziying, Leno Gregory H   +3 more
doaj   +1 more source

Reporter Genes

, 2008
Reporter genes have been widely used in plant molecular biology, typically to discern patterns of gene expression, but also as markers of transformed cells during stable transformation procedures.The ideal marker gene would be expected to display characteristics such as ease and cheapness of use, lack of toxicity, and robustness; and the most commonly ...
openaire   +2 more sources

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source

Novel replication-competent reporter-expressing Rift Valley fever viruses for molecular studies

Journal of Virology
Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic disease that causes severe disease in both domestic and wild ungulates and humans, making it a significant threat to livestock and public health.
Aitor Nogales, Celia Alonso, Sandra Moreno, Gema Lorenzo, Belén Borrego, Luis Martinez-Sobrido, Alejandro Brun   +6 more
doaj   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

Rapid Quantification of Bluetongue Virus-Neutralizing Antibodies Using Bioluminescent Reporter-Expressing Viruses

Vaccines
Bluetongue virus (BTV) is the causative agent of the significant livestock disease Bluetongue (BT), which causes severe economic losses associated with its considerable impact on the health and trade of ruminants. Background/Objectives: BTV infection and
Luis Jiménez-Cabello, Sergio Utrilla-Trigo, Eva Calvo-Pinilla, Aitor Nogales, Javier Ortego   +4 more
doaj   +1 more source

Визначення ліній Drosophіla melanogaster, репортерна система яких чутлива до низьких доз мутагену

Фактори експериментальної еволюції організмів, 2017
Aim. There are many methods of assessment of mutagens, but the effects of low-dose mutagens have been overlooked. In this study we try to select lines of Drosophila melanogaster with high-sensitive to mutagen reporter gene. We used D. melanogaster lines
Ya. S. Yasinskyi, L. V. Omelianchuk, O. V. Zhuk, I. A. Kozeretska   +3 more
doaj   +1 more source

Overview of the reporter genes and reporter mouse models

Animal Models and Experimental Medicine, 2018
AbstractReporter genes are widely applied in biotechnology and biomedical research owning to their easy observation and lack of toxicity. Taking advantage of the reporter genes in conjunction with imaging technologies, a large number of reporter mouse models have been generated. Reporter mouse models provide systems that enable the studies of live cell
Li, Shun, Chen, Li‐xiang, Peng, Xiu‐hua, Wang, Chao, Qin, Bo‐yin, Tan, Dan, Han, Cheng‐xiao, Yang, Hua, Ren, Xiao‐nan, Liu, Fang, Xu, Chun‐hua, Zhou, Xiao‐hui   +11 more
openaire   +2 more sources

The chicken gene nomenclature committee report [PDF]

BMC Genomics, 2009
Comparative genomics is an essential component of the post-genomic era. The chicken genome is the first avian genome to be sequenced and it will serve as a model for other avian species. Moreover, due to its unique evolutionary niche, the chicken genome can be used to understand evolution of functional elements and gene regulation in mammalian species.
Burt, D. W., Carre, W., Fell, Mark, Law, A. S., Antin, P. B., Maglott, D. R., Weber, J. A., Schmidt, C. J., Burgess, S. C., McCarthy, F. M.   +9 more
openaire   +4 more sources