Results 111 to 120 of about 550,187 (318)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Transcription of TIR1-controlled Genes Can be Regulated within 10 Minutes by an Auxin-induced Process. Can TIR1 be the Receptor?

Frontiers in Plant Science, 2016
ABP1 and TIR1/AFBs are known as auxin receptors. ABP1 is linked to auxin responses several of which are faster than ten minutes. TIR1 regulates auxin-induced transcription of early auxin genes also within minutes.
Corinna Labusch, Yunus Effendi, Martin Fulda, Günther F. E. Scherer   +3 more
doaj   +1 more source

Molecular Imaging with Aquaporin-Based Reporter Genes: Quantitative Considerations from Monte Carlo Diffusion Simulations. [PDF]

ACS Synth Biol, 2023
Chowdhury R, Wan J, Gardier R, Rafael-Patino J, Thiran JP, Gibou F, Mukherjee A.   +6 more
europepmc   +1 more source

Mechanism underlying synergic activation of Tyrosinase promoter by MITF and IRF4 [PDF]

, 2017
Background: The transcription factor interferon regulatory factor 4 (IRF4) was identified to be involved in human pigmentation by genome-wide association studies (GWASs).
Cai, Xinzhang, Chen, Hongsheng, Feng, Yong, He, Chufeng, Li, Jiada, Liu, Huadie, Liu, Xueming, Liu, Yalan, Mei, Lingyun, Peng, Zhen, Song, Jian, Vleminckx, Kris   +11 more
core   +1 more source

A beta-glucuronidase reporter gene construct for monitoring aflatoxin biosynthesis in Aspergillus flavus [PDF]

, 1995
Joseph E. Flaherty, Mark A. Weaver, Gary A. Payne, Charles P. Woloshuk   +3 more
openalex   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Beneficial and Pathogenic Arabidopsis Root-Interacting Fungi Differently Affect Auxin Levels and Responsive Genes During Early Infection

Frontiers in Microbiology, 2019
Auxin (indole-3-acetic acid, IAA) is an important phytohormone involved in root growth and development. Root-interacting beneficial and pathogenic fungi utilize auxin and its target genes to manipulate the performance of their hosts for their own needs ...
Anja K. Meents, Anja K. Meents, Anja K. Meents, Alexandra C. U. Furch, Marília Almeida-Trapp, Sedef Özyürek, Sandra S. Scholz, Alexander Kirbis, Teresa Lenser, Günter Theißen, Veit Grabe, Bill Hansson, Axel Mithöfer, Axel Mithöfer, Ralf Oelmüller   +14 more
doaj   +1 more source

A Genetic Programming Approach to Engineering MRI Reporter Genes. [PDF]

ACS Synth Biol, 2023
Bricco AR, Miralavy I, Bo S, Perlman O, Korenchan DE, Farrar CT, McMahon MT, Banzhaf W, Gilad AA.   +8 more
europepmc   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source