Results 131 to 140 of about 357,104 (247)

New approaches for the neuroimaging of gene expression

Frontiers in Integrative Neuroscience, 2015
Assaf A Gilad, Assaf A Gilad, Galit ePelled, Galit ePelled   +3 more
doaj   +1 more source

Reporter genes and transgenic <i>Trypanosoma cruzi</i> (Kinetoplastida, Trypanosomatidae): applications for screening new drugs against Chagas disease. [PDF]

Front Med (Lausanne)
de Sousa Oliveira DS, da Silva ED, Galvão Júnior FF, Moura DMN, Sales-Junior PA, Brelaz-de-Castro MCA, Pereira VRA.   +6 more
europepmc   +1 more source

Genetically Encoded Reporter Genes for MicroRNA Imaging in Living Cells and Animals. [PDF]

Mol Ther Nucleic Acids, 2020
Song Y, Xu Z, Wang F.
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Reporter Gene [PDF]

, 2020
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Development and validation of Mayaro virus with luciferase reporter genes as a tool for antiviral assays. [PDF]

Heliyon
Marinho MDS, Zhang YN, Cassani NM, Santos IA, Costa Oliveira AL, Dos Santos Pereira AK, Corbi PP, Zhang B, Jardim ACG.   +8 more
europepmc   +1 more source

Pathway-specific reporter genes to study stem cell biology. [PDF]

Stem Cells, 2020
Peterson KM, Franchi F, Olthoff M, Chen IY, Paulmurugan R, Rodriguez-Porcel M.   +5 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Directed Evolution of Acoustic Reporter Genes Using High-Throughput Acoustic Screening. [PDF]

ACS Synth Biol
Hurt RC, Jin Z, Soufi M, Wong KK, Sawyer DP, Shen HK, Dutka P, Deshpande R, Zhang R, Mittelstein DR, Shapiro MG.   +10 more
europepmc   +1 more source