Results 171 to 180 of about 2,216,519 (292)

Reporter genes and transgenic <i>Trypanosoma cruzi</i> (Kinetoplastida, Trypanosomatidae): applications for screening new drugs against Chagas disease. [PDF]

Front Med (Lausanne)
de Sousa Oliveira DS, da Silva ED, Galvão Júnior FF, Moura DMN, Sales-Junior PA, Brelaz-de-Castro MCA, Pereira VRA.   +6 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Reporter Gene [PDF]

, 2008
openaire   +2 more sources

Recombinant Influenza A Viruses Expressing Reporter Genes from the Viral NS Segment. [PDF]

Int J Mol Sci
Martinez-Sobrido L, Nogales A.
europepmc   +1 more source

Genetically Encoded Reporter Genes for MicroRNA Imaging in Living Cells and Animals. [PDF]

Mol Ther Nucleic Acids, 2020
Song Y, Xu Z, Wang F.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Development and validation of Mayaro virus with luciferase reporter genes as a tool for antiviral assays. [PDF]

Heliyon
Marinho MDS, Zhang YN, Cassani NM, Santos IA, Costa Oliveira AL, Dos Santos Pereira AK, Corbi PP, Zhang B, Jardim ACG.   +8 more
europepmc   +1 more source

Pathway-specific reporter genes to study stem cell biology. [PDF]

Stem Cells, 2020
Peterson KM, Franchi F, Olthoff M, Chen IY, Paulmurugan R, Rodriguez-Porcel M.   +5 more
europepmc   +1 more source

Reporter Genes

, 2017
Amer M. Najjar, Laura J. Fromme, Shahriar Yaghoubi   +2 more
openaire   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source