Results 11 to 20 of about 347,626 (258)
Frontiers in Cellular and Infection Microbiology, 2022 CRISPR editing has enabled the rapid creation of fluorescent Plasmodium transgenic lines, facilitating a deeper understanding of parasite biology. The impact of genetic perturbations such as gene disruption or the introduction of drug resistance alleles ...
Johanna Hoshizaki +2 more
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Photoacoustic reporter genes for noninvasive molecular imaging and theranostics [PDF]
Journal of Innovative Optical Health Sciences, 2020 Noninvasive molecular imaging makes the observation and comprehensive understanding of complex biological processes possible. Photoacoustic imaging (PAI) is a fast evolving hybrid imaging technology enabling in vivo imaging with high sensitivity and ...
Zhao Lei +4 more
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StORF-Reporter: finding genes between genes
Nucleic Acids Research, 2022 Abstract Large regions of prokaryotic genomes are currently without any annotation, in part due to well-established limitations of annotation tools. For example, it is routine for genes using alternative start codons to be misreported or completely omitted.
Nicholas J Dimonaco +4 more
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Bi-Reporter Vaccinia Virus for Tracking Viral Infections In Vitro and In Vivo
Microbiology Spectrum, 2021 Recombinant viruses expressing reporter genes allow visualization and quantification of viral infections and can be used as valid surrogates to identify the presence of the virus in infected cells and animal models.
Kevin Chiem +7 more
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Journal of Nuclear Medicine, 2008 Noninvasive molecular imaging of dynamic processes has benefited tremendously from the use of reporter genes. These genes encode for proteins that emit light, bind radiolabeled probes, or, as covered in this review, modulate MRI contrast. Reporter genes play a pivotal role in monitoring cell trafficking, gene replacement therapy, protein-protein ...
Assaf A, Gilad +5 more
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Genetic Manipulation of Non-Falciparum Human Malaria Parasites
Frontiers in Cellular and Infection Microbiology, 2021 The development of genetic manipulation of Plasmodium falciparum in the 1980s was key to study malaria biology. Genetically modified parasites have been used to study several aspects of the disease, such as red blood cell invasion, drug resistance ...
Taís Baruel Vieira +2 more
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Covalent 18F-Radiotracers for SNAPTag: A New Toolbox for Reporter Gene Imaging
Pharmaceuticals, 2021 There is a need for versatile in vivo nuclear imaging reporter systems to foster preclinical and clinical research. We explore the applicability of the SNAPTag and novel radiolabeled small-molecule ligands as a versatile reporter gene system for in vivo ...
Sophie Stotz +4 more
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, 2009 Reporter gene assays are versatile and sensitive methods of assaying numerous targets in high-throughput drug-screening programs. A variety of reporter genes allow users a choice of signal that can be tailored to the required sensitivity, the available detection apparatus, the cellular system employed, and the required compatibility with multiplexed ...
Liu, A.M.F. +3 more
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Molecular Therapy: Nucleic Acids, 2013 Despite the development of potent siRNAs that effectively target genes responsible for skin disorders, translation to the clinic has been hampered by inefficient delivery through the stratum corneum barrier and into the live cells of the epidermis ...
Robyn P Hickerson +9 more
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Adenovirus-mediated gene transfer in primary murine adipocytes
Journal of Lipid Research, 2000 The transfer of genes into primary murine adipocytes using an adenovirus system has been developed. A recombinant adenovirus was constructed (expressing green fluorescent protein [GFP] under the control of the strong cytomegalovirus [CMV] promoter and a ...
Ann Vogel Hertzel +2 more
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