Results 161 to 170 of about 816,185 (299)

Multiple Representations’ Ability in Solving Word Problem [PDF]

Proceedings of the 2nd International Conference of Science and Technology for the Internet of Things, ICSTI 2019, September 3rd 2019, Yogyakarta, Indonesia, 2020
Nurrahmawati Nurrahmawati, Cholis Sa’dijah, Sudirman Sudirman, Makbul Muksar   +3 more
openaire   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Flexible neural representation for physics prediction

, 2019
Humans have a remarkable capacity to understand the physical dynamics of objects in their environment, flexibly capturing complex structures and interactions at multiple levels of detail. Inspired by this ability, we propose a hierarchical particle-based
Li, Fei-Fei, Mrowca, Damian, Tenenbaum, Joshua B, Wang, Elias, Yamins, Daniel L. K., Zhuang, Chengxu, Haber, Nick   +6 more
core  

Problem-Solving Based Epistemic Learning Pattern: Optimizing Mathematical Representation Ability of Prospective Teachers and Pharmacists

Educational Process: International Journal
Background/purpose. Although mathematical representation ability is a significant ability and an interesting topic to study, quite a few researchers have studied this ability, and even fewer have examined it through the implementation of epistemic ...
Nyoman Sridana, Naif Mastoor Alsulami, Muhamad Galang Isnawan, I Ketut Sukarma   +3 more
doaj   +1 more source

Multimodal Deep Learning with Attention-Based Fusion for Skin Cancer Diagnosis. [PDF]

Bioengineering (Basel)
Abdelbaki W, Alshaya H, Nasir IM, Tehsin S, Bouchelligua W.   +4 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Enhancing Students’ Mathematical Representation Ability Using the Concrete-Pictorial-Abstract Approach

Mathematical representation ability is basic for others’ mathematical ability, such as understanding ability, communication ability, reasoning ability, and problem-solving ability.
Dahlan, Jarnawi Afghani, Darhim, Darhim, Azmidar, Azmidar   +2 more
core  

A model of multi-view contrastive hypergraph learning for predicting circRNA-disease associations. [PDF]

Sci Rep
Liu J, Yu C, Ma X, Ruan CW, Wang L.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source