Results 131 to 140 of about 409,457 (308)

The Decline of Economic and Political Freedom After Covid‐19: A New Authoritarian Dawn?

Politics and Governance
The response to Covid-19 in both democratic countries (adopting tactics of totalitarian nations) and autocracies (ignoring the scope of the problem) posed a grave threat to life and liberty. Are we slouching towards a new authoritarian dawn?
Christopher A. Hartwell
doaj   +1 more source

Borderline Personality Disorder Experienced By Laney Brooks In I Smile Back Film

, 2021
Borderline Personality Disorder (BPD) is as a pervasive pattern of instability of interpersonal relationships, self-image, and affects, and marked impulsivity that begins by early adulthood and is present in a variety of contexts.
Maria Ulfa, MA., M.Hum, Maria Ulfa, Apreilina   +2 more
core  

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source

Molecular effects of novel mutations in Hesx1/HESX1 associated with human pituitary disorders [PDF]

, 2001
The homeobox gene Hesx1/HESX1 has been implicated in the establishment of anterior pattern in the central nervous system (CNS) in a number of vertebrate species.
Tyrell, R, Warner, J., Beddington, R.S., Stewart, A., Woods, K, McNay, D, Stewart, A, Warner, J, Beddington, RSP, Dattani, M, Brickman, J.M., Tyrell, R., Brickman, JM, Clements, M, Woods, K., Clements, M., McNay, D., Dattani, M.   +17 more
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β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Milieux et mouvements libertaires pendant la Seconde République et la Guerre Civile espagnole

Diacronie. Studi di Storia Contemporanea, 2011
Anarchism is a political current that is distinguished by its diversity and heterogeneity. Yet, the libertarian circles have often been comprehended by historiography in a homogeneous way, contributing to reify their stories.
Arnaud Dolidier est doctorant à l’université Michel de Montaigne Bordeaux 3 avec une thèse intitulée : « Repartir à l’assaut du ciel ! Les mouvements libertaires durant la transition démocratique espagnole : ordre public et actions collectives (1975-1982) », sous la direction de M. François Godicheau. Domaine de recherche: histoire contemporaine de l’Espagne. Il a réalisé les Master 1 et Master 2 entre 2008 et 2010 sous la direction de M. Jean François Soulet et M. François Godicheau à l’université Toulouse 2 Le Mirail sur le thème : « La construction des identités collectives dans le milieu rural andalou pendant la Seconde République ». Il est membre de l’association « Adelante ».
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Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Evolución de la enseñanza pública en Manresa durante la Segunda República y efectos de la represión franquista sobre el profesorado. // Evolution of public education in Manresa during the Second Republic and different Franco regime effects on teachers.

Cabás, 2013
(ES) Las elecciones municipales del 14 de abril de 1931 en España conllevaron el paso de la monarquía a la república y un cambio profundo en las administraciones municipales.
Joan M. Serra Sala
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