Results 131 to 140 of about 416,000 (310)

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Non-Lethal Weapons and the Sensory Repression of Dissent in Democracies

This article examines the use of ‘non-lethal’ weapons (NLWs) by liberal democracies to govern dissent in non-war contexts. We argue that NLWs can enable sensorial governance, specifically through sensory repression of dissent.
Kaul, N., Cachelin, S.
core   +1 more source

Milieux et mouvements libertaires pendant la Seconde République et la Guerre Civile espagnole

Diacronie. Studi di Storia Contemporanea, 2011
Anarchism is a political current that is distinguished by its diversity and heterogeneity. Yet, the libertarian circles have often been comprehended by historiography in a homogeneous way, contributing to reify their stories.
Arnaud Dolidier est doctorant à l’université Michel de Montaigne Bordeaux 3 avec une thèse intitulée : « Repartir à l’assaut du ciel ! Les mouvements libertaires durant la transition démocratique espagnole : ordre public et actions collectives (1975-1982) », sous la direction de M. François Godicheau. Domaine de recherche: histoire contemporaine de l’Espagne. Il a réalisé les Master 1 et Master 2 entre 2008 et 2010 sous la direction de M. Jean François Soulet et M. François Godicheau à l’université Toulouse 2 Le Mirail sur le thème : « La construction des identités collectives dans le milieu rural andalou pendant la Seconde République ». Il est membre de l’association « Adelante ».
doaj  

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Financial liberalization, saving, investment and growth in MENA countries [PDF]

Over the last two decades MENA countries as much of the developing countries have experienced a wave of liberalization of financial sector. The purpose of this paper is three fold: to review the literature on the rationale for financial repression ...
Lahcen ACHY
core  

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

The modernization of repression and resistance: The rise of state-led digital repression in Latin America and the role of National Human Rights Institutions [PDF]

openThis thesis examines the role of National Human Rights Institutions (NHRIs) in safeguarding human rights and democratic principles against state-led digital repression in Latin American democracies during the COVID-19 pandemic.
CARVAJAL SOJO, MARIANA
core  

Evolución de la enseñanza pública en Manresa durante la Segunda República y efectos de la represión franquista sobre el profesorado. // Evolution of public education in Manresa during the Second Republic and different Franco regime effects on teachers.

Cabás, 2013
(ES) Las elecciones municipales del 14 de abril de 1931 en España conllevaron el paso de la monarquía a la república y un cambio profundo en las administraciones municipales.
Joan M. Serra Sala
doaj