Results 121 to 130 of about 409,457 (308)

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

THE CITY AND THE RESURFACING OF THE REPRESSED. SPACE IN THE NOVEL U REGISTRATURI BY ANTE KOVAČIĆ

Fluminensia: Journal for Philological Research, 2009
Together with the decline of the nobility, the city schooling of a country child and the twofold village-city relationship are the key themes of Croatian realism, as well as realism world-wide.
Dejan Durić
doaj  

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Polizei-Durchgangslager Bozen, 1944-45. Cenni di storia

Diacronie. Studi di Storia Contemporanea, 2018
The purpose of this essay is to understand the operating mode of the Polizei-Durchgangslager Bozen (Bolzano) which started during the german occupation in spring 1944 until May 1945.
Carla Giacomozzi è Responsabile dell’Archivio Storico Città di Bolzano/Stadtarchiv Bozen
doaj  

EXTORTION OF TESTIMONY IN CRIMINAL PROCEEDINGS THROUGH THE PRISM OF THE WORK OF THE POLICE AND THE PROSECUTOR’S OFFICE

Годишњак Правног факултета у Бањалуци
In this paper, attention is focused on the criminal offense of extortion of statement, with the intention of the author to take a comprehensive look at the criminal law (substantive) and procedural aspect of this criminal offense.
Садмир Каровић, Марина М. Симовић   +1 more
doaj   +1 more source

The modernization of repression and resistance: The rise of state-led digital repression in Latin America and the role of National Human Rights Institutions [PDF]

openThis thesis examines the role of National Human Rights Institutions (NHRIs) in safeguarding human rights and democratic principles against state-led digital repression in Latin American democracies during the COVID-19 pandemic.
CARVAJAL SOJO, MARIANA
core  

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source