Results 191 to 200 of about 781,740 (337)

CellPolaris: Transfer Learning for Gene Regulatory Network Construction to Guide Cell State Transitions

Advanced Science, EarlyView.
CellPolaris decodes how transcription factors guide cell fate by building gene regulatory networks from transcriptomic data using transfer learning. It generates tissue‐ and cell‐type‐specific networks, identifies master regulators in cell state transitions, and simulates TF perturbations in developmental processes.
Guihai Feng, Xin Qin, Jiahao Zhang, Wuliang Huang, Yiyang Zhang, Wentao Cui, Yao Chen, Shirui Li, Wenhao Liu, Yao Tian, Yana Liu, Jingxi Dong, Ping Xu, Zhenpeng Man, Guole Liu, Zhongming Liang, Xinlong Jiang, Xiaodong Yang, Pengfei Wang, Ge Yang, Hongmei Wang, Xuezhi Wang, Ming‐Han Tong, Yuanchun Zhou, Shihua Zhang, Yiqiang Chen, Yong Wang, Xin Li   +27 more
wiley   +1 more source

Histone modification cross-talk and protein complex diversification confer plasticity to Polycomb repression. [PDF]

Genes Dev
Bonnet J, Triantopoulou E, Birnhäupl J, Lu C, Fuller MT, Müller J.   +5 more
europepmc   +1 more source

Data from Modulation of Navitoclax Sensitivity by Dihydroartemisinin-Mediated MCL-1 Repression in BCR-ABL⁺ B-Lineage Acute Lymphoblastic Leukemia

, 2023
Amit Budhraja, Meghan E. Turnis, Michelle L. Churchman, Anisha Kothari, Xue Yang, Haiyan Xu, Ewa Kamińska, John C. Panetta, David Finkelstein, Charles G. Mullighan, Joseph T. Opferman   +10 more
openalex   +1 more source

Financial repression redux [PDF]

Periods of high indebtedness have historically been associated with a rising incidence of default or restructuring of public and private debts. Sometimes the debt restructuring is subtle and takes the form of, “financial repression.” In the heavily ...
Kirkegaard, Jacob, Reinhart, Carmen, Sbrancia, Belen   +2 more
core   +1 more source

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

Advanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao Chen   +8 more
wiley   +1 more source

Twin Small RNAs and Divergent Fates: The Expansive Regulatory Networks of OmrA and OmrB. [PDF]

Int J Mol Sci
Konarska J, Jaworska K, Lipska P, Raczkowska A.   +3 more
europepmc   +1 more source

Data from Epigenetic Repression of DNA Mismatch Repair by Inflammation and Hypoxia in Inflammatory Bowel Disease–Associated Colorectal Cancer

, 2023
Robert A. Edwards, Mavee Witherspoon, Kehui Wang, Kambiz Afrasiabi, Trang Pham, Lutz Birnbaumer, Steven M. Lipkin   +6 more
openalex   +1 more source

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Retraction Note: Repression of LncRNA PART1 attenuates ovarian cancer cell viability, migration and invasion through the miR-503-5p/FOXK1 axis. [PDF]

BMC Cancer
Li B, Lou G, Zhang J, Cao N, Yu X.
europepmc   +1 more source

From Revisionism to Revolution and Repression

, 2020

openalex   +1 more source