Results 41 to 50 of about 282,080 (169)
A single regulator NrtR controls bacterial NAD+ homeostasis via its acetylation
eLife, 2019 Nicotinamide adenine dinucleotide (NAD+) is an indispensable cofactor in all domains of life, and its homeostasis must be regulated tightly. Here we report that a Nudix-related transcriptional factor, designated MsNrtR (MSMEG_3198), controls the de novo ...
Rongsui Gao +5 more
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Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
The forgotten voices of the militares cassados in Brazil
Brasiliana: Journal for Brazilian Studies, 2013 Forcibly retired military officials whose political rights were withdrawn (militares cassados) during the military regime have previously received no attention from either the military institution or civilians (the State, the general public, and scholars)
Nina Schneider
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«It is necessary to bring sincere thanks to the donators who willingly responded to the call of the church to help in difficult times...»: report on activities of the Parish Council of Omsk Bogoroditze-Bratskaya Church for 1929 [PDF]
Омский научный вестник: Серия "Общество. История. Современность", 2019 This archaeographic publication is devoted to study of history of Orthodoxy in Omsk at the late 1920s. The report on the activities of the Parish Council of Omsk Bogoroditze-Bratskaya Church for 1929 is being introduced into the scientific circulation.
A. V. Sushko
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Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Гуманитарные и юридические исследования, 2021 The article is devoted to one of the most tragic periods in the history of our country - "great terror". The "harmful" processes of the 1930s in the North Caucasus are analyzed on the basis of their reflection in the regional press in 1937.
Elena Strekalova
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eLife, 2019 During infection, pathogens are starved of essential nutrients such as iron and tryptophan by host immune effectors. Without conserved global stress response regulators, how the obligate intracellular bacterium Chlamydia trachomatis arrives at a ...
Nick D Pokorzynski +2 more
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Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
O povo e a polícia: conflitos sociais em O cortiço, de Aluísio Azevedo, e Recordações do escrivão Isaías Caminha, de Lima Barreto // The people and the police: social conflicts in O cortiço, by Aluísio Azevedo, and Recordações do escrivão Isaías Caminha, by Lima Barreto [PDF]
Svět Literatury, 2017 The article focuses on the social conflicts depicted in two excerpts from the novels O cortiço (1890) by Aluísio Azevedo, and Recordações do escrivão Isaías Caminha (1909) by Lima Barreto.
Edu Teruki Otsuka
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