COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
A single regulator NrtR controls bacterial NAD+ homeostasis via its acetylation
eLife, 2019 Nicotinamide adenine dinucleotide (NAD+) is an indispensable cofactor in all domains of life, and its homeostasis must be regulated tightly. Here we report that a Nudix-related transcriptional factor, designated MsNrtR (MSMEG_3198), controls the de novo ...
Rongsui Gao +5 more
doaj +1 more source
Polycomb group protein complexes exchange rapidly in living Drosophila [PDF]
, 2005 Fluorescence recovery after photobleaching (FRAP) microscopy was used to determine the kinetic properties of Polycomb group (PcG) proteins in whole living Drosophila organisms (embryos) and tissues (wing imaginal discs and salivary glands). PcG genes are
Arndt-Jovin, D. +2 more
core
The regions of the herpes simplex virus type 1 immediate early protein Vmwl75 required for site specific DNA binding closely correspond to those involved in transcriptional regulation [PDF]
, 1988 The immediate-early (IE) protein Vmw175 (ICP4) of HSV-1 is required for the transcription of later classes of viral genes and the repression of IE gene expression.
Everett, R.D., Paterson, T.
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Policing the Campus: Academic Repression, Surveillance, and the Occupy Movement [PDF]
, 2015 Book review of Policing the Campus: Academic Repression, Surveillance, and the Occupy Movement, edited by Anthony J. Nocella II and David Gabbard (2013)
Combs, Sandra L.
core +4 more sources
The forgotten voices of the militares cassados in Brazil
Brasiliana: Journal for Brazilian Studies, 2013 Forcibly retired military officials whose political rights were withdrawn (militares cassados) during the military regime have previously received no attention from either the military institution or civilians (the State, the general public, and scholars)
Nina Schneider
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«It is necessary to bring sincere thanks to the donators who willingly responded to the call of the church to help in difficult times...»: report on activities of the Parish Council of Omsk Bogoroditze-Bratskaya Church for 1929 [PDF]
Омский научный вестник: Серия "Общество. История. Современность", 2019 This archaeographic publication is devoted to study of history of Orthodoxy in Omsk at the late 1920s. The report on the activities of the Parish Council of Omsk Bogoroditze-Bratskaya Church for 1929 is being introduced into the scientific circulation.
A. V. Sushko
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Гуманитарные и юридические исследования, 2021 The article is devoted to one of the most tragic periods in the history of our country - "great terror". The "harmful" processes of the 1930s in the North Caucasus are analyzed on the basis of their reflection in the regional press in 1937.
Elena Strekalova
doaj