Results 51 to 60 of about 89,603 (266)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Anti-religious divisions of Soviet State security bodies during inter-patriarchal period in the Russian Orthodox Church (1925-1943)

open access: yesStudia Humanitatis, 2020
Based on rare published and unpublished sources this paper analyses the most famous group of agent files, agent-operative cultivations of special services implemented by state security agencies in relation to Church-monarchical and mystical groups.
Pidhayko Volodymyr Heorhiyovych
doaj  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Conclusion: Accelerating Digital Repression and its Existential Threat to Democracy

open access: yes, 2023
This book has highlighted how the rapid expansion of new and emerging internet and communication technologies (ICTs) has significantly increased any state’s capacity for repression and social control.
Hagen, Olivia, Ogden, Chris
core  

Traverser la Méditerranée ?Lecture de E.-E. Schmitt (2008) et de L.-Ph. Dalembert (2019)

open access: yesBabel: Littératures Plurielles, 2021
This proposed contribution is based on a thematic analysis which deals with the theme of the journey from the place of origin to Europe, in which four characters feature in two different recent novels.
Belabbas Bouterfas
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Capital mobility and financial repression in Italy, 1960-1990 : a public finance perspective [PDF]

open access: yes, 2003
After significant headway towards liberalization of capital movements in the early 1960s, European governments resorted massively to capital controls in the turmoil of the demise of the Bretton Woods system.
Battilossi, Stefano
core  

A single regulator NrtR controls bacterial NAD+ homeostasis via its acetylation

open access: yeseLife, 2019
Nicotinamide adenine dinucleotide (NAD+) is an indispensable cofactor in all domains of life, and its homeostasis must be regulated tightly. Here we report that a Nudix-related transcriptional factor, designated MsNrtR (MSMEG_3198), controls the de novo ...
Rongsui Gao   +5 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

The forgotten voices of the militares cassados in Brazil

open access: yesBrasiliana: Journal for Brazilian Studies, 2013
Forcibly retired military officials whose political rights were withdrawn (militares cassados) during the military regime have previously received no attention from either the military institution or civilians (the State, the general public, and scholars)
Nina Schneider
doaj   +1 more source

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