Results 41 to 50 of about 89,603 (266)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Translational repression in malaria sporozoites

, 2016
Malaria is a mosquito-borne infectious disease of humans and other animals. It is caused by the parasitic protozoan, Plasmodium. Sporozoites, the infectious form of malaria parasites, are quiescent when they remain in the salivary glands of the Anopheles
Min Zhang, Tiffany Tsao, Thomas Li, Oliver Turque   +3 more
core   +1 more source

The reaction of CEPAL during the Chilean authoritarian regime: repression, institutional constraints, and evaluations of the economic model

América Latina en la Historia Económica
Although CEPAL’s ideas and history have attracted considerable historiographical interest, few were written about the institution’s role in its host country’s authoritarian regime. This paper highlights the complex articulation between the institutional
Marcos Taroco Resende
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Regulating repression: roles for the sir4 N-terminus in linker DNA protection and stabilization of epigenetic states. [PDF]

, 2012
Silent information regulator proteins Sir2, Sir3, and Sir4 form a heterotrimeric complex that represses transcription at subtelomeric regions and homothallic mating type (HM) loci in budding yeast.
Ragna Sack, Tsai-Pflugfelder Monika, Gasser, Susan M, Ferreira, Helder C., Kueng Stephanie, Oppikofer, Mariano, Roberts, Emma, Sack, Ragna, Roloff, Tim-Christoph, Gasser, Susan M., Mariano Oppikofer, Chinyen Tsai (163222), Tim-Christoph Roloff (163227), Emma Roberts, Tsai-Pflugfelder, Monika, Helder C. Ferreira (163213), Tsai Chinyen, Ferreira Helder C., Helder C Ferreira, Oppikofer Mariano, Mariano Oppikofer (163208), Kueng, Stephanie, Roloff Tim-Christoph, Ferreira, Helder C, Roberts Emma, Tsai, Chinyen, Stephanie Kueng, Monika Tsai-Pflugfelder, Stephanie Kueng (163200), Susan M Gasser, Ragna Sack (163231), Emma Roberts (163217), Susan M. Gasser (163235), Tim-Christoph Roloff, Monika Tsai-Pflugfelder (163204), Gasser Susan M., Sack Ragna, Chinyen Tsai   +37 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Mbd2 contributes to DNA methylation-directed repression of the Xist gene [PDF]

, 2007
Transcription of the Xist gene triggers X chromosome inactivation in cis and is therefore silenced on the X chromosome that remains active. DNA methylation contributes to this silencing, but the mechanism is unknown.
Hermann, Andrea, Prokhortchouk, Anna, Adie, Karen, Hendrich, Brian, Barr, Helen, Tsai, Hsin-Hao, Berger, Jennifer, Bird, Adrian; id_orcid   +7 more
core   +1 more source

Moral Panic and Repression: The Contentious Politics of Anti-Semitism in Germany

Partecipazione e Conflitto
Moral panics can be used as a mechanism of repression of political and social protests through the definition of activists as challenging the core values of a society.
Donatella della Porta
doaj   +1 more source