The ubiquitin system in normal and infected germinal center B cells
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Translational repression in malaria sporozoites
Malaria is a mosquito-borne infectious disease of humans and other animals. It is caused by the parasitic protozoan, Plasmodium. Sporozoites, the infectious form of malaria parasites, are quiescent when they remain in the salivary glands of the Anopheles
Min Zhang +3 more
core +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Mbd2 contributes to DNA methylation-directed repression of the Xist gene [PDF]
Transcription of the Xist gene triggers X chromosome inactivation in cis and is therefore silenced on the X chromosome that remains active. DNA methylation contributes to this silencing, but the mechanism is unknown.
Hermann, Andrea +7 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Neste artigo, examina-se o funcionamento do Centro de Informações do Exterior (CIEX), órgão do Itamaraty e vinculado ao Serviço Nacional de Informações (SNI) que foi encarregado de espionar políticos e militantes contrários ao regime militar brasileiro ...
Pio Penna Filho
doaj +1 more source
À partir de différentes enquêtes de terrain, cet article retrace les origines du programme de réparation communautaire au Maroc, un programme de développement socioéconomique et culturel en faveur de régions dont les populations relient leur situation ...
Frédéric Vairel
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
L’Arma dei Carabinieri e le attività di prevenzione e repressione delle organizzazioni criminali /The « Arma dei Carabinieri » and the prevention and repression of organized crime / L’Arme des Carabiniers et les activités de prévention et de répression des organisations criminelles [PDF]
Organized crime now has an international face: it controls illegal international activities and all the huge profits made by drug trafficking, the illegal weapons business, money laundering and trafficking of human beings.
Parente Mario
doaj
Transnational Repression: Trends, Tactics, and Policy Recommendations [PDF]
Today, at least 38 countries employ tactics of transnational repression in as many as 91 host states. In what can be called the "toolkit" of authoritarian control, the hydra-heads of transnational repression encompass tactics ranging from surveillance to
Ozeren, Suleyman +4 more
core

