Results 61 to 70 of about 416,000 (310)
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Cine y guerra civil. El conflicto que no termina
Diacronie. Studi di Storia Contemporanea, 2011 La guerra civile è stata e continua ad essere un tema di analisi, riflessione e dibattito sia in Spagna che all’estero. Sin dall’inizio della guerra, 75 anni fa, il cinema è stato usato come mezzo di propaganda.
José-Vidal Pelaz López es Profesor Titular de Historia Contemporánea en la Facultad de Filosofía y Letras de la Universidad de Valladolid. Entre sus líneas de investigación preferentes destacan la Historia de la comunicación social y la Historia política reciente. En relación a la primera podemos citar sus libros Caciques, apóstoles y periodistas. Medios de comunicación, poder y sociedad en Palencia (1898-1939) (2000) y Ver cine. Los públicos cinematográficos en el siglo XX (2002). Respecto a la segunda El Estado de las Autonomías. Nacionalismos y regionalismos en la Historia Contemporánea de España (2002), Winston Churchill. Auge y declive del Imperio británico (2003) y Castilla y León en democracia. Partidos, elecciones y personal político (1977-2007) (2007). Ha publicado también numerosos capítulos de libros y artículos en publicaciones especializadas. +1 more
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Control and signal processing by transcriptional interference
Molecular Systems Biology, 2009 A transcriptional activator can suppress gene expression by interfering with transcription initiated by another activator. Transcriptional interference has been increasingly recognized as a regulatory mechanism of gene expression. The signals received by
Antoine Buetti‐Dinh +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Dissent Repression Nexus in the Middle East 2008 [PDF]
, 2008 The University Archives has determined that this item is of continuing value to OSU's history.The Middle East is often seen as caught in a cycle of dissent and repression, influencing almost all aspects of existence.
Meyer, Katherine, Jenkins, J. Craig
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Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Journal of Transnational American Studies, 2011 <p>This essay argues that Chang-rae Lee’s novel A Gesture Life exemplifies both the conceptual gains and the potential pitfalls of current Asian American literature’s transnationalism.
Belinda Kong
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Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Вестник Самарского университета: История, педагогика, филологияThe purpose of the article is to reflect the activities of N.A. Voznesensky as head of the State Planning Committee of the USSR, at the same time deputy, and then first deputy chairman of the Council of People’s Commissars (Council of Ministers) of the ...
O. B. Mozokhin
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