Results 31 to 40 of about 409,457 (308)

Regulating repression: roles for the sir4 N-terminus in linker DNA protection and stabilization of epigenetic states. [PDF]

, 2012
Silent information regulator proteins Sir2, Sir3, and Sir4 form a heterotrimeric complex that represses transcription at subtelomeric regions and homothallic mating type (HM) loci in budding yeast.
Ragna Sack, Tsai-Pflugfelder Monika, Gasser, Susan M, Ferreira, Helder C., Kueng Stephanie, Oppikofer, Mariano, Roberts, Emma, Sack, Ragna, Roloff, Tim-Christoph, Gasser, Susan M., Mariano Oppikofer, Chinyen Tsai (163222), Tim-Christoph Roloff (163227), Emma Roberts, Tsai-Pflugfelder, Monika, Helder C. Ferreira (163213), Tsai Chinyen, Ferreira Helder C., Helder C Ferreira, Oppikofer Mariano, Mariano Oppikofer (163208), Kueng, Stephanie, Roloff Tim-Christoph, Ferreira, Helder C, Roberts Emma, Tsai, Chinyen, Stephanie Kueng, Monika Tsai-Pflugfelder, Stephanie Kueng (163200), Susan M Gasser, Ragna Sack (163231), Emma Roberts (163217), Susan M. Gasser (163235), Tim-Christoph Roloff, Monika Tsai-Pflugfelder (163204), Gasser Susan M., Sack Ragna, Chinyen Tsai   +37 more
core   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

NR2F1 disrupts synergistic activation of the MTTP gene transcription by HNF-4α and HNF-1α

Journal of Lipid Research, 2012
Regulation of microsomal triglyceride transfer protein (MTP) expression mainly occurs at the transcriptional level. We have previously shown that MTTP gene expression was repressed in nondifferentiated intestinal cells by nuclear receptor 2 family 1 ...
Kezhi Dai, M. Mahmood Hussain
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

A Repression of Czechoslovak Citizens in the USSR

Acta Universitatis Sapientiae: European and Regional Studies, 2015
Around 30,000 citizens of pre-war Czechoslovakia were persecuted in the Soviet Union, at least 5.000 originated from Czech lands. One of the groups consist of the people who in the period of 1939-1942 sought refuge in the USSR from German or Hungarian ...
Hornik Jan
doaj   +1 more source

Self, Society, and Repression in Babel: A Psychoanalytic Perspective

Journal of Asian Social Science Research, 2019
As the prevailing studies tend to neglect how media depict the sociological question about the relationship between self and society and the dualism between pleasure and reality in modern society, this article examines this important issue by analyzing ...
A.M. Iqbal
doaj   +1 more source

Anger: what we know and what we don't want to know. Scientific contributions and social representation.

Mediterranean Journal of Clinical Psychology, 2020
Introduction: Aggressiveness is an essential component of every living thing and the experience of anger is common to all historical periods, all ages and all mental structures. Different forms and narrative ways of anger can be found in each society and
Paola Manfredi
doaj   +1 more source

Great Purge Period of the Soviet Union in Kazakhstan (1937-1938)

Avrasya İncelemeleri Dergisi, 2023
The Bolsheviks came to power in Russia with the October Revolution under the leadership of Vladimir Ilyich Lenin and established the Union of the Soviet Socialist Republics in 1922. Josef Stalin, who took over the administration after the death of Lenin,
Nurullah Çetin, İlyas Topsakal
doaj   +1 more source

The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain [PDF]

, 2014
BCL6 is a transcriptional repressor that is over-expressed due to chromosomal translocations, or other abnormalities, in ~40% of diffuse large B-cell lymphoma.
Simon D. Wagner (530388), Jamieson, Andrew G, Louise Fairall, Simon D Wagner, Wagner, Simon D, Jamieson Andrew G., Schwabe John W. R., Ko Ferrigno Paul, John W. R. Schwabe (7604093), Paul Ko Ferrigno (41085), Goult, Benjamin T., Wagner, SD, Benjamin T Goult, Evans, SE, Ford, Robert, Sian E Evans, Schwabe, JWR, Andrew G Jamieson, Fairall, Louise, Andrew G. Jamieson (530386), Wagner, Simon D., Benjamin T. Goult (173495), Sian E. Evans (7622282), Ko Ferrigno, Paul, Evans, Sian E, Robert Ford (89276), Ford Robert, Schwabe, John W R, Goult Benjamin T., P. Ko Ferrigno (7674905), Evans Sian E., Fairall, L, Fairall Louise, Schwabe, John W.R., Simon D. Wagner (7633943), John W R Schwabe, Evans, Sian E., Goult, Benjamin T, Goult, BT, Robert Ford, Jamieson, Andrew G., Louise Fairall (530385), Ko Ferrigno, P, Ford, R, John W. R. Schwabe (530387), Jamieson, AG, Wagner Simon D., Sian E. Evans (530384), Paul Ko Ferrigno, R. Ford (7674908)   +49 more
core   +1 more source