Results 291 to 300 of about 382,695 (354)

KAP1 in antiviral immunity: dual roles in viral silencing and immune regulation. [PDF]

Front Cell Infect Microbiol
Xin R, Garigliany MM, Li J.
europepmc   +1 more source

Tumor Intrinsic METTL5 Modulates ATF4 Translation to Prevent T Cell‐Induced Ferroptosis in Ovarian Cancer

Advanced Science, EarlyView.
An integrative analysis combining in vitro genome‐wide immune screens, in vivo ICB screens, and clinical data mining identifies METTL5 as a key tumor‐intrinsic immune factor. Mechanistic studies further reveal the importance of the METTL5‐ATF4‐SLC7A11/SLC3A2‐ferroptosis axis in modulating antitumor immune responses. These findings highlight METTL5 as a
Jiakai Hou, Cheng‐Wei Ju, Nicholas A. Egan, Yanjun Wei, Yunfei Wang, Minghao Dang, Tianyi Zhou, Leilei Shi, Ningbo Zheng, Si Chen, Ashley M. Guerrero, Xiaofang Liang, Wanfu Wu, Areej Akhtar, Chitra Dhiman, Debanwita Roy Burman, Andro E. Gerges, Mason D. Flores, Han Li, Li‐Sheng Zhang, Marleen Kok, Xiaobo Mao, Linghua Wang, Qin Feng, Yiwen Chen, Sanghoon Lee, Daniel J. McGrail, Nidhi Sahni, Chuan He, Amir A. Jazaeri, Weiyi Peng   +30 more
wiley   +1 more source

Insight into the Role of the BCL6B Gene in Biological Functions and Disease Progression. [PDF]

J Cancer
Pan Y, Li Y.
europepmc   +1 more source

A Refined Adaptive Laboratory Evolution Strategy With Biosensor‐Assisted Selection Resolves the Tolerance–Efficiency Trade‐Off in Toxic Chemical Biosynthesis

Advanced Science, EarlyView.
This study presents a refined adaptive laboratory evolution (ALE) strategy to resolve the trade‐off between tolerance and biosynthetic efficiency in toxic chemical production. Combining in vivo mutagenesis, microdroplet‐based evolution, and biosensor‐assisted selection, this strategy rapidly yields robust “win‐win” phenotypes.
Yufei Zhang, Junhua Yun, Guoyan Zhang, Hossain M. Zabed, Yuehui Tian, Xinrui Tang, Jia Li, Xianghui Qi   +7 more
wiley   +1 more source

All-in-one vectors for epigenetic CRISPR inhibition of <i>DUX4-fl</i> in facioscapulohumeral muscular dystrophy. [PDF]

Mol Ther Methods Clin Dev
Himeda CL, Jones TI, Jones PL.
europepmc   +1 more source

CRYing for balance: a repressor lingers through peak circadian transcription. [PDF]

EMBO J
Brunner M.
europepmc   +1 more source

Examining the Roles of Genomic Context and Endogenous Regulatory Elements on IS<i>1</i> Transposition Within the <i>Escherichia coli</i> Genome. [PDF]

Int J Mol Sci
Smith S, Zhang Z, Ho A, Karnani T, Ord J, Saier MH.   +5 more
europepmc   +1 more source

Phosphorylation deficient inducible cAMP early repressor (ICER) modulates tumorigenesis and survival in a transgenic zebrafish (Danio rerio) model of melanoma. [PDF]

Biol Open
Wheelan J, Spigelman M, Cirinelli A, Reilly J, Molina CA.   +4 more
europepmc   +1 more source

Acetylation of lysine 49 on Ctnnb1 drives naïve pluripotency in murine stem cells by modulating Nanog function. [PDF]

PNAS Nexus
Takehara T, Nakanishi M, Son R, Suemori H, Murakawa Y, Teramura T.   +5 more
europepmc   +1 more source

Identification of OxyR as an activator of type 1 fimbriae (<i>fim</i>) in <i>Salmonella enterica</i> serovar Typhi. [PDF]

Microbiol Spectr
Dufresne K, Ou C, Badet M, Cadieux G, Daigle F.   +4 more
europepmc   +1 more source