Results 211 to 220 of about 191,078 (267)

CauFinder: Steering Cell‐State and Phenotype Transitions by Causal Disentanglement Learning

Advanced Science, EarlyView.
CauFinder combines causal disentanglement modeling and network control to prioritize causal drivers of cell‐state transitions from observational transcriptomic data. The framework separates transition‐relevant signals from spurious associations, nominates intervention targets across biological and disease contexts, and identifies DAAM1 as an actionable
Chengming Zhang, Zexi Chen, Yuanxiang Miao, Zuolin Shen, Deyu Cai, Shijie Tang, Yun Xue, Weifeng Guo, Hongbin Ji, Jian Liu, Kazuyuki Aihara, Luonan Chen   +11 more
wiley   +1 more source

Mycobacteriophage Mcgavigan Uses Noncanonical Bxb1-Like Repressor for Heterotypic Superinfection Immunity. [PDF]

J Basic Microbiol
Shafer N, Dubrule BE, De Buck J.
europepmc   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

FOXC2 represses NFAT1-dependent transcription through a DNA-facilitated protein-protein interaction. [PDF]

Nucleic Acids Res
Chen X, Wu S, Yue S, Zhang L, Liu X, Dai S, Li J, Zhang H, Wei H, Guo M, Qu L, Chen L, Deng Y, Chen Y.   +13 more
europepmc   +1 more source

Molecular mechanisms and applications of antimicrobial secondary metabolites of <i>Bacillus subtilis</i> based on biofilm and quorum sensing. [PDF]

Appl Environ Microbiol
Feng J, Luo H, Zhang Z, Wang Z, Wang M.
europepmc   +1 more source

CRISPR Interference to Inhibit Oncogenes for Cancer Therapy. [PDF]

Int J Mol Sci
Guo B.
europepmc   +1 more source

SWEET tea: transcriptional regulation of sugar transporters in stress and development. [PDF]

J Exp Bot
Zhang X, Liesche J.
europepmc   +1 more source

Epigenetically regulated transcriptional repressor, BASIC PENTACYSTEINE1 (BPC1) acts together with polycomb repressive complex 2 (PRC2) to suppress camalexin biosynthesis in Arabidopsis. [PDF]

Plant Mol Biol
Moon H, Choi D, Cho E, Kim H, Nugroho ABD, Kim DH.   +5 more
europepmc   +1 more source

Conserved Motifs in the Ligand-Binding Domain of TetR Family Regulators: Identification and Analysis. [PDF]

Comput Struct Biotechnol J
Kepa M, Nielipinski M, Widawska E, Filipek J, Kazmierczak N, Sosnowska J, Baca K, Nastarowicz M, Rupp M, Goslawski-Zeligowski M, Mokrzycka J, Nielipinska D, Sekula B, Pietrzyk-Brzezinska AJ.   +13 more
europepmc   +1 more source