Results 221 to 230 of about 191,078 (267)
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The retinoblastoma protein as a transcriptional repressor
Trends in Cell Biology, 1993The retinoblastoma protein (pRB) is one of the best-studied tumour suppressor gene products. Its loss during the genesis of many human tumours, its inactivation by several DNA tumour virus oncoproteins, and its ability to inhibit cell growth when introduced into dividing cells all suggest that pRB negatively regulates some aspect of normal cell growth.
Helin, K, Ed, H
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Bacteriophage Coat Protein as Repressor
Nature, 1968It seems that viral coat protein acts as a repressor of protein synthesis at the level of transcription rather than translation.
H, Robertson, R E, Webster, N D, Zinder
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Modelling repressor proteins docking to DNA
Proteins: Structure, Function, and Genetics, 1998The docking of repressor proteins to DNA starting from the unbound protein and model-built DNA coordinates is modeled computationally. The approach was evaluated on eight repressor/DNA complexes that employed different modes for protein/ DNA recognition.
P, Aloy +5 more
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Plasmid-mediated isolation of a repressor protein
Analytical Biochemistry, 1980Abstract A multicopy chimeric plasmid enriched for operator sequences has been used to mobilize and isolate a repressor protein. The procedure relies on the intact isolation of a plasmid DNA-protein complex, precipitation of the complex with polyethylene glycol, ionic elution of the bound protein, and final purification on phosphocellulose columns ...
R K, Koduri, J, Matthews, J S, Gots
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PIAS Proteins as Repressors of Oct4 Function
Journal of Molecular Biology, 2007The POU domain transcription factor Oct4 plays essential functions in the maintenance of pluripotent embryonic and germ cells of mammals. Molecular mechanisms of Oct4 action remain poorly understood. To isolate modulators of Oct4 activity, we performed a yeast two-hybrid screen with the Oct4 POU domain as a bait and isolated PIASy as an Oct4 ...
Tolkunova, E. +5 more
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Regulation in repressor inactivation by RecA protein
Advances in Biophysics, 1990Treatments that damage DNA or inhibit DNA synthesis in E. coli induce the expression of a set of functions called SOS functions that are involved in DNA repair, mutagenesis, arrest of cell division and prophage induction. Induction of SOS functions is triggered by inactivation of the LexA repressor or a phage repressor. Inactivation of these repressors
H, Ogawa, T, Ogawa
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Strigolactone Signaling: Repressor Proteins Are Transcription Factors
Trends in Plant Science, 2020A recent landmark study by Wang et al. provides new insight into transcriptional regulation in strigolactone (SL) signaling. The finding that SUPPRESSOR OF MAX2 LIKE 6 (SMXL6) also functions as an autoregulated transcription factor (TF) causes a paradigm shift in the current view of transcriptional repressors in phytohormone signaling.
Jiuyou Tang, Chengcai Chu
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Lac repressor is a transient gene-activating protein
Cell, 1987We show, using a combination of methods, that contrary to the usual view, lac repressor increases, by more than 100-fold, the initial binding of RNA polymerase to E. coli lac UV5 promoter DNA. Kinetic studies revealed that the repressor acts to block the isomerization step in transcription initiation.
S B, Straney, D M, Crothers
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Modification of tyrosine residues of the lactose repressor protein
Biochimica et Biophysica Acta (BBA) - Protein Structure, 1977Reaction of the lactose repressor protein from Escherichia coli with high molar excesses (up to 800 fold) of tetranitromethane resulted in modification of tyrosine residues in the amino-terminal and core regions of the molecule. Tyrosines 7 and 17 exhibit significant reactivity at low levels (5-10 fold molar excess) of tetranitromethane.
M E, Alexander +4 more
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Thermal denaturation of the core protein of lac repressor
Biochemistry, 1985The thermal denaturation of the core protein of lac repressor was studied alone and in the presence of the inducer isopropyl beta-D-thiogalactoside (IPTG) and the antiinducer o-nitrophenyl beta-D-fucoside (ONPF) by means of high-sensitivity differential scanning calorimetry.
S P, Manly +2 more
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