Results 221 to 230 of about 1,854,175 (305)

Mitochondrial protein COXFA4L3 (C15ORF48) confers resistance to DNA-damaging anticancer agents by repressing mitochondrial DNA damage responses

Yuki Takakura, Seika Kawamura, Yui Hashiguchi, Manami Yamanaka, Yasuyuki Kurihara, Taishin Akiyama, Hiroyuki Takano, Noritaka Yamaguchi   +7 more
openalex   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Isoform-paralog specificity and tissue-dependent vulnerabilities in neurological disorders. [PDF]

Genes Dev
Hernandez-Quijada K, Kwan KY.
europepmc   +1 more source

RETRACTION : A‐Kinase‐Interacting Protein 1 Overexpression Correlates With Deteriorative Tumor Features and Worse Survival Profiles and Promotes Cell Proliferation but Represses Apoptosis in Non‐Small‐Cell Lung Cancer

openalex   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Heme as a versatile signaling molecule: Coordinating mitochondrial metabolism with global cellular responses. [PDF]

J Biol Chem
Chitrakar I, Brown BL.
europepmc   +1 more source

FOXC2 represses NFAT1-dependent transcription through a DNA-facilitated protein–protein interaction

Xiaojuan Chen, Sipeng Wu, Sitong Yue, Lin Zhang, Xueru Liu, Shuyan Dai, J Li, Haitao Zhang, Hudie Wei, Ming Guo, Lingzhi Qu, LL Chen, Yalan Deng, Yongheng Chen   +13 more
openalex   +1 more source

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

Hexokinase 2 and Carbohydrate Metabolism: A Multifaceted Metabolic Hub. [PDF]

Genes (Basel)
Maslanka R, Folta J, Lubińska M, Słota Ł, Zadrag-Tecza R.   +4 more
europepmc   +1 more source

Correction to ‘RNA binding protein Musashi1 interacts with the viral genomic RNA and restricts SARS-CoV-2 infection by repressing translation’

openalex   +1 more source