Results 241 to 250 of about 1,762,100 (297)

A phage repressor involved in the DNA-damage response of <i>Francisella</i>. [PDF]

PNAS Nexus
Pérez-Varela M, Sánchez-Osuna M, Campoy S, Aranda J, Barbé J, Erill I.   +5 more
europepmc   +1 more source

Programmable Encapsulation Enables On‐Demand Proliferation of Therapeutic Bacteria for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang, Ao Peng, Shuaiqiang Li, Yaning Huang, Jian Yan, Leyuan Wang, Zhihui Zhu, Fei‐Long Liu, Erbao Bian, Yang Liu, Dasheng Tian, Fenghe Li, Qi Liu   +12 more
wiley   +1 more source

Signal Transducing Adaptor Protein-2 Represses Epithelial-Mesenchymal Transition by Downregulating SMAD-Mediated ZEB1 Expression. [PDF]

Genes Cells
Okuyama F, Kitai Y, Li Z, Ishii M, Muromoto R, Matsuda T.   +5 more
europepmc   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

CenIR, an essential BlaIR-family regulatory system in <i>C. difficile</i>. [PDF]

J Bacteriol
Kurtz MP, Müh U, Weiss DS, Ellermeier CD.   +3 more
europepmc   +1 more source

Herbicide Metabolic Resistance in Poaceae Plants via the GA‐GID1/DELLA‐DOF2‐P450s Module

Advanced Science, EarlyView.
Plant hormone signaling modulates herbicide resistance in Echinochloa crus‐galli. The GA–DELLA–DOF2 cascade directly activates P450 detoxification genes in two Poaceae species, uncovering a core mechanism of metabolic herbicide resistance. ABSTRACT Barnyard grass (Echinochloa crus‐galli) is one of the world's most important weeds, and the evolution of ...
Junzhi Wang, Jiale Qi, Lin Wei, Qin Yu, Zhongyuan Liu, Lianyang Bai, Lang Pan   +6 more
wiley   +1 more source

Molecular Mechanisms of Transcription Factors with Dual Activator and Repressor Functions. [PDF]

Mol Cell Biol
Dong J, Guertin MJ.
europepmc   +1 more source

Cyclic di-GMP directly reprograms the multidrug resistance machinery via UspG-mediated sequestration of RamR in Klebsiella. [PDF]

PLoS Pathog
Liu X, Wang M, Fu Y, Zhu X, Du M, Wen Y, Liao Y, Zhao Y, Deng Y, Gu B.   +9 more
europepmc   +1 more source

Functional impact of a conservative missense mutation in the Mycobacterium bovis BCG Moreau heat shock response regulator hrcA gene. [PDF]

BMC Microbiol
Gomes LHF, Antunes D, Correa PR, Schwarz MGA, Mendonça-Lima L.   +4 more
europepmc   +1 more source

Reorientation of the SUMOylation landscape and altered L3mbtl2-mediated transcriptional activity in cancer-associated muscle contractile dysfunction. [PDF]

Cell Death Discov
Gand LV, Li M, Brandt K, Zhou B, Nassar-Grioua A, Gondin J, Becker E, Pich A, Kraft T, Amrute-Nayak M, Nayak A.   +10 more
europepmc   +1 more source