Results 241 to 250 of about 1,854,175 (305)

RNA binding protein Musashi1 interacts with the viral genomic RNA and restricts SARS-CoV-2 infection by repressing translation

Sourav Ganguli, Divya Gupta, Rajashekar Varma Kadumuri, Dixit Tandel, Rajashree Ramaswamy, Aswathy G Krishnan, Deena T David, Soumya Bunk, Sreenivas Chavali, Krishnan Harinivas Harshan, Pavithra Lakshminarasimhan Chavali   +10 more
openalex   +1 more source

Companion cells with high florigen production express other small proteins and reveal a nitrogen-sensitive FT repressor [PDF]

Hiroshi Takagi, Shogo Ito, Jae Sung Shim, Akane Kubota, Andrew K Hempton, Nayoung Lee, Takamasa Suzuki, Jared S. Wong, Chansie Yang, Christine T Nolan, Kerry L. Bubb, Cristina M Alexandre, Daisuke Kurihara, Yoshikatsu Sato, Yasuomi Tada, Takatoshi Kiba, José L. Pruneda-Paz, Christine Queitsch, Josh T. Cuperus, Takato Imaizumi   +19 more
openalex   +1 more source

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

Advanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen, Haiyang Gao, Wang Wu, Pengzhi Shi, Yuhang Chen, Anran Zhang, Zhangrong Cheng, Wenbo Wu, Zimu Yu, Yukun Zhang   +9 more
wiley   +1 more source

Should I stay or should I go? DNA damage thresholds drive stay-or-go decisions in <i>Acinetobacter baumannii</i> biofilms. [PDF]

J Bacteriol
Nguyen B, Godoy-Carter V.
europepmc   +1 more source

The PbTCP2–PbTCP4 protein complex promotes pear flowering by suppressing transcription of the flowering-repressor gene PbSVP

Hongjuan Zhang, Jingjing Cheng, Kaile Liu, Hongbo Xia, Yutong Wang, Zesheng Wang, Jingjing Miao, Guangya Sha, Rui Zhai, Chengquan Yang, Zhigang Wang, Lingfei Xu   +11 more
openalex   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Design and evolution of the tetracycline repressor into sulfonylurea herbicide-responsive gene switches for field crops. [PDF]

Nat Commun
McBride KE, Kakani NK, Bozhanova NG, Fang J, Lowe K, Leija C, McGonigle B, Schreiter ER, Hermanson F, Chan M, Arling M, Wang N, Cho HJ, Richey C, Hoerster G, Marvin JS, Lenderts B, McReynolds MR, Hastings C, Madrigal A, Falco SC, Lassner MW, Anand A, Gordon-Kamm W, Looger LL.   +24 more
europepmc   +1 more source

A BSCB‐Penetrating Nanoplatform for Enhanced Luteolin Delivery in PRMT2‐Targeted Epigenetic Therapy of Spinal Cord Injury

Advanced Science, EarlyView.
In this work, MSN‐BO@LUT penetrates the blood‐spinal cord barrier for luteolin delivery in spinal cord injury. The nanodrug suppresses neuroinflammation and promotes functional recovery of the spinal cord. Mechanistically, luteolin targets protein arginine N‐methyltransferase (PRMT2) to decrease toll‐like receptor 4 (TLR4) methylation, thereby ...
Yixuan Wang, Bo Jin, Shipian Li, Qianxi Ouyang, Yu Xiao, Jiaxin Wen, Yehua Lai, Ping Wang, Yongjun Wang, Xuejun Cui, Weian Zhang, Min Yao   +11 more
wiley   +1 more source

Small Anther, a C₂H₂-Type Zinc Finger Transcription Repressor, Controls Rice Anther Length Through Regulation of Epidermal Cell Division. [PDF]

Plants (Basel)
Wu J, Liu Y, Xia Y, Tao Y, Zhao L, Lu K, Liang W, Chen T, Wang C, Zhang Y, Zhao C, An H.   +11 more
europepmc   +1 more source