Results 251 to 260 of about 290,663 (301)

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source

Engineering Basal Cognition: Minimal Genetic Circuits for Habituation, Sensitization, and Massed-Spaced Learning. [PDF]

ACS Synth Biol
Pla-Mauri J, Solé R.
europepmc   +1 more source

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source

A GA-independent, membrane-associated pathway regulates DELLA degradation during carbon/nitrogen stress. [PDF]

Plant Cell
Chia JC.
europepmc   +1 more source

Proteins driving liquid-liquid phase separation and histone modifications cooperatively associate with chromatin looping and transcriptional regulation. [PDF]

Epigenetics Chromatin
Ji X, Nie Y.
europepmc   +1 more source

Mapping the phenotypic landscape of a transcriptional repressor using deep mutational scanning and growth-based quantitative sequencing. [PDF]

Nucleic Acids Res
Jansen Z, Le X, Wei Q, Kulhanek DL, Alperovich N, Vasilyeva O, Gilmour AR, Ross D, Thyer R.   +8 more
europepmc   +1 more source

Regulation of zygotic genome activation by the nucleocytoplasmic ratio. [PDF]

Front Cell Dev Biol
Acker L, Chen H.
europepmc   +1 more source

Novel <i>Bacillus</i>-Infecting Phage <i>Bquatquinnuvirus eskimopiis</i> (Strains B450T and B450C), Founder of a New Genus, and the Properties of Its Endolysin. [PDF]

Int J Mol Sci
Kazantseva OA, Koposova ON, Shorokhova IA, Kulyabin VA, Shadrin AM.   +4 more
europepmc   +1 more source