Results 251 to 260 of about 1,854,175 (305)

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

A Bacillus Phage From Bangladeshi Soil, Phage APU1: Genomic Characterisation and Comparative Genomic Analysis. [PDF]

Environ Microbiol Rep
Haider A, Esha TJ, Rahman S, Akther J, Faysal NI, Khan T, Mondal SI, Begum A, Biswas SK, Rahman M, Jubair M.   +10 more
europepmc   +1 more source

A State‐Gated Metallo‐DNAzyme Framework Programs Tumor Stress Vulnerability Through Metabolic Licensing

Advanced Science, EarlyView.
A tumor‐state‐gated metallo‐DNAzyme framework integrates miR‐21/APE1‐responsive GLUT1 silencing with Ca/Cu‐partitioned metal–nucleic acid assembly and cystine loading. The framework first weakens glucose‐dependent metabolic buffering and then amplifies copper‐ and disulfide‐associated stress, converting tumor metabolic adaptation into programmable ...
Xiaodong Ma, Lingyun He, Xinru Wang, Yuanyuan Wei, Chengcheng Li, Jiaqi Yan, Weijian Sun, Xian Shen, Hongbo Zhang   +8 more
wiley   +1 more source

Expanding the TBL1XR1 Disease Spectrum: Generalized Dystonia Associated with a New Genetic Variant. [PDF]

Tremor Other Hyperkinet Mov (N Y)
Löw MJ, Bernsdorff F, Weinrich C, Biskup S, Jüngling J, van Riesen C, Maass F.   +6 more
europepmc   +1 more source

TGFβ pathway represses hepatic ribosome biogenesis and protein synthesis by regulating p70S6K–S6RP proteins

Athanasios Stavropoulos, Vassiliki Stamatopoulou, Eleftherios Pavlos, Maria Manioudaki, Stratigoula Sakellariou, Constantinos Stathopoulos, Maria Xilouri   +6 more
openalex   +1 more source

Epigenetic Reactivation of TNFRSF19 Suppresses Mitophagy and Sensitizes Triple‐Negative Breast Cancer to Doxorubicin

Advanced Science, EarlyView.
TNFRSF19 is an epigenetically silenced regulator of mitophagy in triple‐negative breast cancer. TNFRSF19 deficiency activates the TGFBR1–SMAD3–PINK1 axis to promote mitophagy and confer doxorubicin resistance, whereas decitabine‐mediated restoration of TNFRSF19 suppresses mitophagy and enhances doxorubicin sensitivity, revealing a targetable epigenetic–
Shiyang Liu, Chenguang Liu, Weihong Zheng, Xiaofei Tong, Zhengwei Gui, Zonghong Lu, Sun Ieong, Lin Zhang   +7 more
wiley   +1 more source

Genetic Toolbox Expansion Enables Constitutively Fluorescent Lacticaseibacillus rhamnosus for Functional Microbiome Research. [PDF]

Microb Biotechnol
Van Tente I, Blanch-Asensio M, Eilers T, Vandenheuvel D, Lebeer S, Sankaran S, Spacova I.   +6 more
europepmc   +1 more source

ZINC FINGER PROTEIN 1 and 8 interact with polycomb repressive complex 2 to repress class B and C floral organ identity genes

Tieqiang Hu, Liren Du, Mingli Xu
openalex   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source