Results 261 to 270 of about 290,663 (301)

Bacteriophage Coat Protein as Repressor

Nature, 1968
It seems that viral coat protein acts as a repressor of protein synthesis at the level of transcription rather than translation.
H, Robertson, R E, Webster, N D, Zinder
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Strigolactone Signaling: Repressor Proteins Are Transcription Factors

Trends in Plant Science, 2020
A recent landmark study by Wang et al. provides new insight into transcriptional regulation in strigolactone (SL) signaling. The finding that SUPPRESSOR OF MAX2 LIKE 6 (SMXL6) also functions as an autoregulated transcription factor (TF) causes a paradigm shift in the current view of transcriptional repressors in phytohormone signaling.
Jiuyou Tang, Chengcai Chu
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Modelling repressor proteins docking to DNA

Proteins: Structure, Function, and Genetics, 1998
The docking of repressor proteins to DNA starting from the unbound protein and model-built DNA coordinates is modeled computationally. The approach was evaluated on eight repressor/DNA complexes that employed different modes for protein/ DNA recognition.
P, Aloy, G, Moont, H A, Gabb, E, Querol, F X, Aviles, M J, Sternberg   +5 more
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Plasmid-mediated isolation of a repressor protein

Analytical Biochemistry, 1980
Abstract A multicopy chimeric plasmid enriched for operator sequences has been used to mobilize and isolate a repressor protein. The procedure relies on the intact isolation of a plasmid DNA-protein complex, precipitation of the complex with polyethylene glycol, ionic elution of the bound protein, and final purification on phosphocellulose columns ...
R K, Koduri, J, Matthews, J S, Gots
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The retinoblastoma protein as a transcriptional repressor

Trends in Cell Biology, 1993
The retinoblastoma protein (pRB) is one of the best-studied tumour suppressor gene products. Its loss during the genesis of many human tumours, its inactivation by several DNA tumour virus oncoproteins, and its ability to inhibit cell growth when introduced into dividing cells all suggest that pRB negatively regulates some aspect of normal cell growth.
Helin, K, Ed, H
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Regulation in repressor inactivation by RecA protein

Advances in Biophysics, 1990
Treatments that damage DNA or inhibit DNA synthesis in E. coli induce the expression of a set of functions called SOS functions that are involved in DNA repair, mutagenesis, arrest of cell division and prophage induction. Induction of SOS functions is triggered by inactivation of the LexA repressor or a phage repressor. Inactivation of these repressors
H, Ogawa, T, Ogawa
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PIAS Proteins as Repressors of Oct4 Function

Journal of Molecular Biology, 2007
The POU domain transcription factor Oct4 plays essential functions in the maintenance of pluripotent embryonic and germ cells of mammals. Molecular mechanisms of Oct4 action remain poorly understood. To isolate modulators of Oct4 activity, we performed a yeast two-hybrid screen with the Oct4 POU domain as a bait and isolated PIASy as an Oct4 ...
Tolkunova, E., Malashicheva, A., Parfenov, V., Sustmann, C., Grosschedl, R., Tomilin, A.   +5 more
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Escherichia coli Repressor Proteins

1989
Genetic regulation is an essential function in all living organisms. In prokaryotes genetic control provides responsivity to a constantly changing external milieu, and bacterial systems have proved extremely valuable in elucidating the variety of potential mechanisms.
Kyle L. Wick, Kathleen S. Matthews
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Ultraviolet difference spectra of the lactose repressor protein

Biochimica et Biophysica Acta (BBA) - Protein Structure, 1973
Abstract Ultraviolet difference spectra of the lactose repressor have been studied under various conditions. Changes in the aromatic residues of the protein upon addition of inducers, but not anti-inducers, are found. The extent of exposure of aromatic residues to solvent perturbation is also found to differ in the presence of inducers and anti ...
K S, Matthews, H R, Matthews, H W, Thielmann, G, Jardetzky   +3 more
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Lactose Repressor Protein: Functional Properties and Structure

1997
The lactose repressor protein (LacI), the prototype for genetic regulatory proteins, controls expression of lactose metabolic genes by binding to its cognate operator sequences in E. coli DNA. Inducer binding elicits a conformational change that diminishes affinity for operator sequences with no effect on nonspecific binding. The release of operator is
K S, Matthews, J C, Nichols
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