Results 261 to 270 of about 1,854,175 (305)

A T7 RNAP regulatory toolbox for cell-free network engineering and biosensing applications. [PDF]

Nat Commun
Lee PW, Mottaghi SS, Lugnier MG, Maerkl SJ.   +3 more
europepmc   +1 more source

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

Advanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu, Xingwei Xie, Xiaohuan Wu, Suidong Ouyang, Yang Zhou, Kang Wen, Yutong Zhong, Yuyang Chen, Handuo Wang, Yuan Gao, Ling Jiang, Hui Li, Wenli Zhao, Abai Xu, Enguang Bi   +14 more
wiley   +1 more source

The Role of the Omega Subzone in Determining the Membership of a Protein in One of the Two Families of the LexA/Signal Peptidase-like Superfamily. [PDF]

Int J Mol Sci
Denesyuk AI, Denessiouk K, Johnson MS, Uversky VN.   +3 more
europepmc   +1 more source

TaMYB44 represses grain protein content by directly binding to the promoters of HMW-GS genes in wheat

Yujiao Gao, Weiyi Xia, Lizhi Jiang, Xinyi Tan, Yi Dai, Yonggang Wang, Haigang Ma, Hongxiang Ma   +7 more
openalex   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Recent advances in epigenetic therapeutics for Rett syndrome: from mechanisms to clinical trials. [PDF]

Front Behav Neurosci
Zhao C, Huang Z, Li R, Hua L, Li H, Wang B.   +5 more
europepmc   +1 more source

The XRE family protein DbuR is a transcriptional repressor of the dbu operon in Pseudomonas putida

Ronnie L. Fulton, Diana M. Downs
openalex   +1 more source

Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis

Advanced Science, EarlyView.
Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao, Ting‐Yu Han, Yan‐Li Cheng, Yi‐Dan Zhang, Yu‐Wei Zhang, JinJian Guo, ShaoJun Zhang, WenZe Huang, Jing Zhang, Pei‐Yu Liao, Ying Xin, ChuanChen Chu, Qing‐Yuan Sun, ZhiZhen Liu, Xiang‐Hong Ou, Jun Xie   +15 more
wiley   +1 more source

From hijackers to architects: the role of prophages in bacterial genome evolution. [PDF]

J Bacteriol
Rubí-Rangel L, León-Félix J, Villicaña C.   +2 more
europepmc   +1 more source

The telomeric valine–arginine dipeptide repeat protein changes state to diffuse staining in mitosis and represses in vitro translation

Taghreed M. Al-Turki, Venkata Mantri, Smaranda Willcox, Christine A. Mills, Laura E. Herring, Su-Ji Cho, Hannah Lee, Caliyn Meyer, Eva S. Anton, Jack D. Griffith   +9 more
openalex   +1 more source