Results 101 to 110 of about 1,729,850 (302)

Reliability of 2D motion analysis software for evaluation of dynamic smile asymmetry using smartphone technology

Clinical and Investigative Orthodontics
Aim To evaluate the reliability of a free motion analysis method in the evaluation of the 2D dynamic asymmetry of smiles using smartphone technology.Materials and methods Twenty-six healthy adult females were included in this study. Four facial bilateral
Dhelal Al-Rudainy, Hadeel Adel Al-Lami, Talib Al-Ameri, Liu Yang   +3 more
doaj   +1 more source

The Polygenic Score Catalog as an open database for reproducibility and systematic evaluation

Nature Genetics, 2021
Samuel A. Lambert, Laurent Gil, S. Jupp, S. Ritchie, Yu Xu, A. Buniello, A. McMahon, Gad Abraham, Michael Chapman, Helen Parkinson, J. Danesh, J. MacArthur, M. Inouye   +12 more
semanticscholar   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Quantifying Statistical Heterogeneity and Reproducibility in Cooperative Multi-Agent Reinforcement Learning: A Meta-Analysis of the SMAC Benchmark

Algorithms
This study presents the first quantitative meta-analysis in cooperative multi-agent reinforcement learning (MARL). Undertaken on the StarCraft Multi-Agent Challenge (SMAC) benchmark, we quantify reproducibility and statistical heterogeneity across ...
Rex Li, Chunyu Liu
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

No Reproducibility, No Progress: Rethinking CT Benchmarking

Journal of Imaging
Reproducibility is a cornerstone of scientific progress, yet in X-ray computed tomography (CT) reconstruction, it remains a critical and unresolved challenge. Current benchmarking practices in CT are hampered by the scarcity of openly available datasets,
Dmitry Polevoy, Danil Kazimirov, Marat Gilmanov, Dmitry Nikolaev   +3 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Immunoglobulin G genetic variation can confound assessment of antibody levels via altered binding to detection reagents

Clinical & Translational Immunology
Objectives Amino acid variations across more than 30 immunoglobulin (Ig) allotypes may introduce structural changes that influence recognition by anti‐Ig detection reagents, consequently confounding interpretation of antibody responses, particularly in ...
Ruth A Purcell, L Carissa Aurelia, Robyn Esterbauer, Lilith F Allen, Katherine A Bond, Deborah A Williamson, Janine M Trevillyan, Jason A Trubiano, Jennifer J Juno, Adam K Wheatley, Miles P Davenport, Thi HO Nguyen, Katherine Kedzierska, Stephen J Kent, Kevin John Selva, Amy W Chung   +15 more
doaj   +1 more source

A Fair Comparison in Deep Learning-Based QSM Reconstruction

IEEE Access
In medical imaging, deep learning has greatly enhanced image quality, however, issues on the generalization of network performance for datasets of untrained characteristics (i.e., out-of-distribution data) have risen.
Chungseok Oh, Woojin Jung, Jiye Kim, Hwihun Jeong, Jongho Lee   +4 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source