Results 141 to 150 of about 978,638 (304)
2023 09 21 Antibodies and research reproducibility
These are resources from the UKRN webinar "Antibodies and research reproducibility: A technical, open data sharing, behavioural, and policy challenge" which took place on Thursday 21 September 2023. Antibodies are one of the most important tools used in
UK Reproducibility Network
core +2 more sources
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
Grand Rounds: Research Reproducibility - Julio C. Facelli, PhD (01-30-2018)
, 2018 Spencer S. Eccles Health Sciences Library Grand Rounds: Research Reproducibility (GRRR). "Uncertainty Quantification for Biomedical Decision Making: A Critical Informatics Contribution to Precision Medicine"" presented by Julio C.
Julio C. Facelli, PhD
core
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Reproducibility & the Prevention of Bias: Before, During & After Research (Mayden Lecture)
, 2016 Research Reproducibility Conference 2016, Priscilla M. Mayden Lecture: Hilda Bastian (NIH)
Hilda Bastian
core
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Research Reproducibility 2016: Snyder Lecture by John Ioannidis
, 2016 Research Reproducibility Conference 2016, University of Utah. Jean Shipman introduces the Snyder Lecturer, John Ioannidis (Stanford) "How Can Universities Help Make More Published Research True / Reproducible?
John Ioannidis
core