Results 131 to 140 of about 978,638 (304)

Ensuring robustness in scientific research, split-root assays as an example case

Quantitative Plant Biology
Scientific progress relies on reproducibility, replicability, and robustness of research outcomes. After briefly discussing these terms and their significance for reliable scientific discovery, we argue for the importance of investigating robustness of ...
Lucila Salvatore, Ronald Pierik, Kaisa Kajala, Kirsten ten Tusscher   +3 more
doaj   +1 more source

Research Reproducibility 2016: John Ioannidis Q&A

, 2016
Research Reproducibility Conference 2016 - Q&A session with John Ioannidis (Stanford) "How Can Universities Help Make More Published Research True / Reproducible?
John Ioannidis
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Transparency, quality, and statistical consistency of meta-analytic systematic reviews in clinical child and adolescent psychology (2022–2024): study protocol for a meta-review

Frontiers in Psychology
Meta-analytic systematic reviews are crucial for advancing research and practice in Clinical Child and Adolescent Psychology (CCAP). Despite their importance, there has been no systematic investigation into transparency- and quality-related aspects of ...
Magdalena Siegel, Selina Fanninger, Julia Riedel, Martina Zemp   +3 more
doaj   +1 more source

Reproducible research and reproducibility checks

Presentation for the Rotterdam R.I.O.T. Science Club about reproducible research and reproducibility checks. Presented March 18, 2025 Part of the Repro Checks project for the 2024-2025 eScience Center fellowship.
openaire   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Grand Rounds: Research Reproducibility - Alan H. Morris, MD (03-06-2018)

, 2018
Spencer S. Eccles Health Sciences Library Grand Rounds: Research Reproducibility (GRRR). "A new Conceptual Model for Coordinating Different Strategies to Enhance Replicability." GRRR is a weekly endeavor to raise awareness about reproducibility issues ...
Alan H. Morris, MD
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Grand Rounds: Research Reproducibility - Tom Greene, PhD (04-17-2018)

, 2018
Spencer S. Eccles Health Sciences Library Grand Rounds: Research Reproducibility (GRRR). "The Role of Post-Hoc Analyses the Error Term in Reproducible Research - A Statistical Perspective" presented by Tom Greene, PhD.
Tom Greene, PhD
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source