Results 81 to 90 of about 1,729,850 (302)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Registration and reporting of clinical trials affiliated with California universities and with primary completion date from 2014 to 2017

Trials
Background Public information on US clinical trials is shared through the ClinicalTrials.gov registry. This study’s goal was to determine prospective registration, results reporting, trial registration number reporting, and publication accessibility ...
Mario Malički, Vladislav Nachev, Susanne Wieschowski, Nicole Hildebrand, Stefanie Gestrich, Samruddhi Yerunkar, Emmanuel Zavalis, Benjamin Gregory Carlisle, Delwen L. Franzen, Maia Salholz-Hillel, Steven N. Goodman, Daniel Strech   +11 more
doaj   +1 more source

Enhancing E-Government Services through State-of-the-Art, Modular, and Reproducible Architecture over Large Language Models

Applied Sciences
Integrating Large Language Models (LLMs) into e-government applications has the potential to improve public service delivery through advanced data processing and automation.
George Papageorgiou, Vangelis Sarlis, Manolis Maragoudakis, Christos Tjortjis   +3 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Intra and Inter-Rater Variability in the Interpretation of White Blood Cell Scintigraphy of Hip and Knee Prostheses

Diagnostics
Background: White blood cell (WBC) scintigraphy plays a major role in the diagnostic approach to periprosthetic infections. Although the procedure has been standardized by the publication of several guidelines, the interpretation of this technique may be
Giuseppe Campagna, Chiara Lauri, Ringo Manta, Roberta Ottaviani, Walter Davide Vella, Alberto Signore   +5 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

HiCRep: assessing the reproducibility of Hi-C data using a stratum-adjusted correlation coefficient

bioRxiv, 2017
Hi-C is a powerful technology for studying genome-wide chromatin interactions. However, current methods for assessing Hi-C data reproducibility can produce misleading results because they ignore spatial features in Hi-C data, such as domain structure and
Tao Yang, Feipeng Zhang, G. Yardımcı, R. Hardison, William Stafford Noble, Feng Yue, Qunhua Li   +6 more
semanticscholar   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Investigating Reproducibility Challenges in LLM Bugfixing on the HumanEvalFix Benchmark

Software
Benchmark results for large language models often show inconsistencies across different studies. This paper investigates the challenges of reproducing these results in automatic bugfixing using LLMs, on the HumanEvalFix benchmark.
Balázs Szalontai, Balázs Márton, Balázs Pintér, Tibor Gregorics   +3 more
doaj   +1 more source

A checklist for maximizing reproducibility of ecological niche models

Nature Ecology & Evolution, 2019
Reporting specific modelling methods and metadata is essential to the reproducibility of ecological studies, yet guidelines rarely exist regarding what information should be noted.
Xiao Feng, Daniel S. Park, Cassondra M. Walker, A. Peterson, C. Merow, M. Papeş   +5 more
semanticscholar   +1 more source