Results 81 to 90 of about 690,617 (311)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Quantifying Statistical Heterogeneity and Reproducibility in Cooperative Multi-Agent Reinforcement Learning: A Meta-Analysis of the SMAC Benchmark

Algorithms
This study presents the first quantitative meta-analysis in cooperative multi-agent reinforcement learning (MARL). Undertaken on the StarCraft Multi-Agent Challenge (SMAC) benchmark, we quantify reproducibility and statistical heterogeneity across ...
Rex Li, Chunyu Liu
doaj   +1 more source

“photosearcher” package in R: An accessible and reproducible method for harvesting large datasets from Flickr [PDF]

, 2020
Nathan Fox, Tom August, Francesca Mancini, Katherine E. Parks, Felix Eigenbrod, James M. Bullock, Louis Sutter, Laura Graham   +7 more
openalex   +1 more source

Reproducibility of an Intraoperative Pressure Sensor in Total Knee Replacement [PDF]

, 2021
Camdon Fary, Dean McKenzie, Richard de Steiger   +2 more
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

No Reproducibility, No Progress: Rethinking CT Benchmarking

Journal of Imaging
Reproducibility is a cornerstone of scientific progress, yet in X-ray computed tomography (CT) reconstruction, it remains a critical and unresolved challenge. Current benchmarking practices in CT are hampered by the scarcity of openly available datasets,
Dmitry Polevoy, Danil Kazimirov, Marat Gilmanov, Dmitry Nikolaev   +3 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Immunoglobulin G genetic variation can confound assessment of antibody levels via altered binding to detection reagents

Clinical & Translational Immunology
Objectives Amino acid variations across more than 30 immunoglobulin (Ig) allotypes may introduce structural changes that influence recognition by anti‐Ig detection reagents, consequently confounding interpretation of antibody responses, particularly in ...
Ruth A Purcell, L Carissa Aurelia, Robyn Esterbauer, Lilith F Allen, Katherine A Bond, Deborah A Williamson, Janine M Trevillyan, Jason A Trubiano, Jennifer J Juno, Adam K Wheatley, Miles P Davenport, Thi HO Nguyen, Katherine Kedzierska, Stephen J Kent, Kevin John Selva, Amy W Chung   +15 more
doaj   +1 more source

A Fair Comparison in Deep Learning-Based QSM Reconstruction

IEEE Access
In medical imaging, deep learning has greatly enhanced image quality, however, issues on the generalization of network performance for datasets of untrained characteristics (i.e., out-of-distribution data) have risen.
Chungseok Oh, Woojin Jung, Jiye Kim, Hwihun Jeong, Jongho Lee   +4 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source