Results 81 to 90 of about 1,117,074 (345)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Reproducibility, reliability and validity of measurements obtained from Cecile3 digital models

Brazilian Oral Research, 2009
The aim of this study was to determine the reproducibility, reliability and validity of measurements in digital models compared to plaster models. Fifteen pairs of plaster models were obtained from orthodontic patients with permanent dentition before ...
Gustavo Adolfo Watanabe-Kanno, Jorge Abrão, Hiroshi Miasiro Junior, Alfonso Sánchez-Ayala, Manuel O. Lagravère   +4 more
doaj   +1 more source

Reproducibility and replication of research results

International Journal on Software Tools for Technology Transfer
Abstract While a reproducible research result can be independently confirmed by third parties using artifacts provided by the original authors, replicating a research result means to independently obtain it using new measurements, data, or implementations.
Dirk Beyer, Arnd Hartmanns
openaire   +2 more sources

Reproducibility of liquid oxygen impact test results [PDF]

Results for 12,000 impacts on a wide range of materials were studied to determine the reproducibility of the liquid oxygen impact test method. Standard deviations representing the overall variability of results were in close agreement with the expected ...
Gayle, J. B.
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Benchmarking urine storage and collection conditions for evaluating the female urinary microbiome. [PDF]

, 2019
Standardized conditions for collection, preservation and storage of urine for microbiome research have not been established. We aimed to identify the effects of the use of preservative AssayAssure® (AA), and the effects of storage time and temperatures ...
Brubaker, Linda, Chopyk, Jessica, Jung, Carrie E, Knight, Rob, Lukacz, Emily S, Pride, David T, Schwanemann, Leila K, Shin, Ji Hyun, Wolfe, Alan J   +8 more
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Agreement Between the WHOQOL-BREF Chinese and Taiwanese Versions in the Elderly

Journal of the Formosan Medical Association, 2009
The brief version of the World Health Organization Quality of Life instrument (WHOQOL-BREF), including four domains, has been culturally adapted into Taiwan Chinese and Taiwanese versions for different targeted populations of elderly people.
Chi-Wen Chien, Jung-Der Wang, Grace Yao, I-Ping Hsueh, Ching-Lin Hsieh   +4 more
doaj   +1 more source