Results 81 to 90 of about 4,106,574 (383)

Questionable Answers in Question Answering Research: Reproducibility and Variability of Published Results

Transactions of the Association for Computational Linguistics, 2018
“Based on theoretical reasoning it has been suggested that the reliability of findings published in the scientific literature decreases with the popularity of a research field” (Pfeiffer and Hoffmann, 2009).
Matt Crane
semanticscholar   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Validity and reliability of fluoroscopy for digital radiography: a new way to evaluate diaphragmatic mobility

BMC Pulmonary Medicine, 2017
Background Fluoroscopy is considered the most accurate method to evaluate the diaphragm, yet most existing methods for measuring diaphragmatic mobility using fluoroscopy are complex.
Bruna Estima Leal, Márcia Aparecida Gonçalves, Liseane Gonçalves Lisboa, Larissa Martins Schmitz Linné, Michelle Gonçalves de Souza Tavares, Wellington Pereira Yamaguti, Elaine Paulin   +6 more
doaj   +1 more source

Bioconductor: open software development for computational biology and bioinformatics. [PDF]

, 2004
The Bioconductor project is an initiative for the collaborative creation of extensible software for computational biology and bioinformatics. The goals of the project include: fostering collaborative development and widespread use of innovative software,
Bates, Douglas, Bolstad, Ben, Carey, Vincent, Dettling, Marcel, Dudoit, Sandrine, Ellis, Byron, Gautier, Laurent, Ge, Yongchao, Gentleman, Robert, Gentry, Jeff, Hornik, Kurt, Hothorn, Torsten, Huber, Wolfgang, Iacus, Stefano, Irizarry, Rafael, Leisch, Friedrich, Li, Cheng, Maechler, Martin, Rossini, Anthony, Sawitzki, Gunther, Smith, Colin, Smyth, Gordon, Tierney, Luke, Yang, Jean, Zhang, Jianhua   +24 more
core   +7 more sources

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Assessment of physical fitness among non-athlete adolescents: Effect of familiarization sessions

Baltic Journal of Health and Physical Activity, 2020
Background: ‪The validity and reliability of fitness tests are described in the literature; however, the effects of familiarization sessions on motor performance have not yet been studied.
DIOGO HENRIQUE CONSTANTINO COLEDAM, RODRIGO DIAS CARIA DE OLIVEIRA   +1 more
doaj   +1 more source

Self-Estimated Functional Inability because of Pain questionnaire for Brazilian workers with musculoskeletal pain: face and content validity

Fisioterapia e Pesquisa, 2021
Our study aimed to perform the face and content validity of Self-Estimated Functional Inability because of Pain (SEFIP) for workers, here called the SEFIP-work questionnaire. This is a questionnaire validity study.
Cezar Augusto Brito Pinheiro, Cid André Fidelis-de-Paula-Gomes, Vinício dos Santos Barros, Josane Soares Pinto Melo, Daniela Bassi-Dibai, Almir Vieira Dibai-Filho   +5 more
doaj   +1 more source

Reproducibility and repeatability of measuring the electrical impedance of the pregnant human cervix-the effect of probe size and applied pressure [PDF]

, 2009
Background: The utility of cervical electrical impedance spectroscopy (EIS) as a diagnostic tool is being investigated in clinical trials. We sought to assess the reliability of two different sizes of tetrapolar probes used in measuring cervical ...
Anumba, D.O.C., Brown, B.H., Ghule, V.V., Jokhi, R.P.   +3 more
core   +3 more sources

Reproducible Results Policy [PDF]

Journal of Water Resources Planning and Management, 2021
David E. Rosenberg, Amber Spackman Jones, Yves Filion, Rebecca Teasley, Samuel Sandoval-Solis, James H. Stagge, Adel Abdallah, Anthony Castronova, Avi Ostfeld, David Watkins   +9 more
openaire   +2 more sources

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source