Results 101 to 110 of about 614,762 (328)
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
Brucella NyxA and NyxB dimerization enhances effector function during infection
FEBS Letters, EarlyView.Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre +4 more
wiley +1 more source
A Guide to Reproducibility in Preclinical Research
Academic Medicine, 2019 Many have raised concerns about the reproducibility of biomedical research. In this Perspective, the authors address this “reproducibility crisis” by distilling discussions around reproducibility into a simple guide to facilitate understanding of the topic. Reproducibility applies both within and across studies.
Greg Samsa, Leigh Ann Samsa
openaire +4 more sources
FEBS Letters, EarlyView.UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg +2 more
wiley +1 more source
Environmental Data ScienceIn this paper, we explore the crucial role and challenges of computational reproducibility in geosciences, drawing insights from the Climate Informatics Reproducibility Challenge (CICR) in 2023.
Alejandro Coca-Castro +5 more
doaj +1 more source
Public engagement with research reproducibility [PDF]
PLOS BiologyPublic engagement with reproducibility is crucial for fostering trust in science. This Community Page outlines, through the example of baking Christmas tree meringues, how scientists can effectively engage and educate the public about the importance of reproducibility in research.
Constant Vinatier +6 more
openaire +2 more sources
arXiv, 2020 Reproducibility has been consistently identified as an important component of scientific research. Although there is a general consensus on the importance of reproducibility along with the other commonly used 'R' terminology (i.e., Replicability, Repeatability etc.), there is some disagreement on the usage of these terms, including conflicting ...
arxiv
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
The Vienna LTE simulators - Enabling reproducibility in wireless communications research
EURASIP Journal on Advances in Signal Processing, 2011 In this article, we introduce MATLAB-based link and system level simulation environments for UMTS Long-Term Evolution (LTE). The source codes of both simulators are available under an academic non-commercial use license, allowing researchers full access ...
Mehlführer Christian +5 more
doaj
Exploration of reproducibility issues in scientometric research Part 1: Direct reproducibility [PDF]
arXiv, 2018 This is the first part of a small-scale explorative study in an effort to start assessing reproducibility issues specific to scientometrics research. This effort is motivated by the desire to generate empirical data to inform debates about reproducibility in scientometrics.
arxiv