Results 101 to 110 of about 2,140,003 (260)

Single-cell analysis of fetal testis reveals dysfunction of human Leydig cells in Klinefelter syndrome

The Journal of Clinical Investigation
Klinefelter syndrome (KS), the most common sex chromosome aneuploidy (affecting approximately 1 in 650 live male births), causes severe infertility. The extra X chromosome can impair the development of fetal germ cells, but its effects on somatic cells ...
Tong Yan, Guancheng Chen, Jie Zhang, Wenjing Jia, Nan Lu, Shuping Jin, Haotian Zhang, Yichen Zhao, Lu Jiang, Jing Wu, Qing Liu, Chenghao Situ, Hui Zhu, Yan Li, Quan Wang, Xiaoyu Yang, Chao Qin, Xiaofeng Song, Qing Cheng, Xuejiang Guo   +19 more
doaj   +1 more source

Social Network Analysis of Scientific Collaboration in the Field of Reproductive Biology in Iran

مدیریت اطلاعات سلامت, 2017
Introduction: In the recent decades, emerging and novel issues have been proposed in the field of reproductive biology leading to increased scientific outputs by scholars.
Rashid Jafarzadeh, Davoud Haseli
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Single-cell mapping of human endometrium and decidua reveals epithelial and stromal contributions to fertility

JCI Insight
The human endometrium undergoes dynamic changes across the menstrual cycle to establish a receptive state for embryo implantation. Using bulk and single-cell RNA-Seq, we characterized gene expression dynamics in the cycling endometrium and the decidua ...
Gregory W. Burns, Emmanuel N. Paul, Manisha Persaud, Qingshi Zhao, Rong Li, Kristin Blackledge, Jessica Garcia de Paredes, Pratibha Shukla, Ripla Arora, Anat Chemerinski, Nataki C. Douglas   +10 more
doaj   +1 more source

Hyaluronan control of the primary vascular barrier during early mouse pregnancy is mediated by uterine NK cells

JCI Insight, 2020
Successful implantation is associated with a unique spatial pattern of vascular remodeling, characterized by profound peripheral neovascularization surrounding a periembryo avascular niche.
Ron Hadas, Eran Gershon, Aviad Cohen, Ofir Atrakchi, Shlomi Lazar, Ofra Golani, Bareket Dassa, Michal Elbaz, Gadi Cohen, Raya Eilam, Nava Dekel, Michal Neeman   +11 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Elevated CCL2 causes Leydig cell malfunction in metabolic syndrome

JCI Insight, 2020
Metabolic syndrome (MetS), which is associated with chronic inflammation, predisposes males to hypogonadism and subfertility. The underlying mechanism of these pathologies remains poorly understood.
Qingkui Jiang, Constanze C. Maresch, Sebastian Friedrich Petry, Agnieszka Paradowska-Dogan, Sudhanshu Bhushan, Yongsheng Chang, Christine Wrenzycki, Hans-Christian Schuppe, Petr Houska, Michaela F. Hartmann, Stefan A. Wudy, Lanbo Shi, Thomas Linn   +12 more
doaj   +1 more source

The Centre for Reproductive Biology in Uppsala

The primary function of the Centre for Reproductive Biology in Uppsala (CRU) "is to increase the knowledge about reproduction in animals and humans by applying a more comprehensive view on reproductive biology." CRU is composed of scientists ...

core  

Regional patterns in reproductive biology of Lethrinus miniatus on the Great Barrier Reef

, 2006
Uniformity in fish population biology is a common assumption in many fishery assessments and management arrangements. Although spatial patterns in population biology are often unknown, ignorance of significant variation within a fished stock has profound
Mapstone, B.D., Davies, C.R., Williams, A.J.   +2 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source