Tumor mutational burden as a determinant of metastatic dissemination patterns
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Effects of Pharmaceuticals and Endocrine-Disrupting Chemicals on Reproductive Biology of Aquatic Fauna: Penguins as Sentinel Species. [PDF]
Okuthe GE, Dube E, Mafunda PS.
europepmc +1 more source
New horizons in the reproductive biology of Chinese pangolin (Manis pentadactyla) using the gonadal hormonal profile. [PDF]
Arora B, Pei KJ, Chin SC.
europepmc +1 more source
BIOLOGI REPRODUKSI IKAN SEPATUNG, Pristolepis Grootii Blkr. 1852 (NANDIDAE) DI SUNGAI MUSI [Reproductive Biology of Indonesian Leaffish, Pristolepis Grootii, Blkr. 1852 (Nandidae) in Musi River] [PDF]
Yunizar Emawati +2 more
openalex +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Knowing the reproductive biology and reproductive success of Scrophularia oxyrhyncha Coincy as a first step for its conservation. [PDF]
Rodríguez-Riaño T +6 more
europepmc +1 more source
Reproductive Biology and Breeding Systems of Two Opisthopappus Endemic and Endangered Species on the Taihang Mountains. [PDF]
Wang Y +6 more
europepmc +1 more source
Reproductive Biology of the Cownose Ray in the Charlotte Harbor Estuarine System, Florida
Gregg R. Poulakis
openalex +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source

