Results 51 to 60 of about 1,879,235 (344)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
The Journal of Clinical Investigation, 2023 SARS-CoV-2 infection during pregnancy is associated with severe COVID-19 and adverse fetal outcomes, but the underlying mechanisms remain poorly understood. Moreover, clinical studies assessing therapeutics against SARS-CoV-2 in pregnancy are limited. To
Patrick S. Creisher +12 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Fetal and maternal NLRP3 signaling is required for preterm labor and birth
JCI Insight, 2022 Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. One of every 4 preterm neonates is born to a mother with intra-amniotic inflammation driven by invading bacteria.
Kenichiro Motomura +14 more
doaj +1 more source
GPI-AP release in cellular, developmental, and reproductive biology
Journal of Lipid Research, 2016 Glycosylphosphatidylinositol-anchored proteins (GPI-APs) contain a covalently linked GPI anchor located on outer cell membranes. GPI-APs are ubiquitously conserved from protozoa to vertebrates and are critical for physiological events such as development,
Yoshitaka Fujihara, M. Ikawa
semanticscholar +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Management, Resources and Reproductive Biology [PDF]
Journal of Systemics, Cybernetics and Informatics, 2014 This work presents a relationship between environmental conditions and reproductive performance in modern humans. Birth rates and sex ratio (SRB) at birth were analyzed from large data scales.
Bernard Wallner, Martin Fieder
doaj
Karyopherin α deficiency contributes to human preimplantation embryo arrest
The Journal of Clinical Investigation, 2023 Preimplantation embryo arrest (PREMBA) is a common cause of female infertility and recurrent failure of assisted reproductive technology. However, the genetic basis of PREMBA is largely unrevealed.
Wenjing Wang +31 more
doaj +1 more source
Reproductive tract biology: Of mice and men.
Differentiation; research in biological diversity, 2019 The study of male and female reproductive tract development requires expertise in two separate disciplines, developmental biology and endocrinology.
G. Cunha +5 more
semanticscholar +1 more source