Results 61 to 70 of about 739,587 (347)
Fetal and maternal NLRP3 signaling is required for preterm labor and birth
JCI Insight, 2022 Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. One of every 4 preterm neonates is born to a mother with intra-amniotic inflammation driven by invading bacteria.
Kenichiro Motomura +14 more
doaj +1 more source
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Karyopherin α deficiency contributes to human preimplantation embryo arrest
The Journal of Clinical Investigation, 2023 Preimplantation embryo arrest (PREMBA) is a common cause of female infertility and recurrent failure of assisted reproductive technology. However, the genetic basis of PREMBA is largely unrevealed.
Wenjing Wang +31 more
doaj +1 more source
Reproductive Biology of Silurid Catfishes Ompok Miostoma (Vaillant 1902) in Mahakam River East Kalimantan [PDF]
, 2019 Biologi reproduksi ikan lais O. miostoma (Vaillant 1902)sebagai salah satu spesies endemik di Sungai Mahakam Kalimantan Timur belum pernah diketahui. Tujuan penelitian ini adalah menganalisisaspek reproduksi ikan laisberkaitan dengan Perubahan musimyang ...
Affandi, R. (Ridwan) +4 more
core
The Animal Sexes as Historical Explanatory Kinds [PDF]
, 2020 Though biologists identify individuals as ‘male’ or ‘female’ across a broad range of animal species, the particular traits exhibited by males and females can vary tremendously.
Franklin-Hall, Laura
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Increased hepatic glucose production with lower oxidative metabolism in the growth-restricted fetus
JCI InsightFetal growth restriction (FGR) is accompanied by early activation of hepatic glucose production (HGP), a hallmark of type 2 diabetes (T2D). Here, we used fetal hepatic catheterization to directly measure HGP and substrate flux in a sheep FGR model.
Laura D. Brown +6 more
doaj +1 more source
TP63 gain-of-function mutations cause premature ovarian insufficiency by inducing oocyte apoptosis
The Journal of Clinical Investigation, 2023 The transcription factor p63 guards genome integrity in the female germline, and its mutations have been reported in patients with premature ovarian insufficiency (POI).
Chengzi Huang +8 more
doaj +1 more source
Reproductive biology of blue marlin (Makaira nigricans) in the western Pacific Ocean [PDF]
, 2009 The reproductive biology of blue marlin (Makaira nigricans) was assessed from 1001 fish (ranging from 121 to 275 cm in eye-to-fork length; EFL) caught by Taiwanese offshore longliners in the western Pacific Ocean from September 2000 to December ...
Chien-Chung Tszeng, Chien-Chung Tszeng +3 more
core
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source