Results 91 to 100 of about 1,229,803 (292)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Insufficient NNMT promotes autophagy and disrupts progesterone signaling in endometrial stromal cells in recurrent implantation failure by modulating the H3K9me3-ALDH1A3 pathway

Cell Death Discovery
Defective endometrial receptivity represents an important factor in recurrent implantation failure (RIF), though its precise regulatory mechanisms remain unclear.
Yifei Song, Shaotong Zhao, Xianping Hou, Jiayuan Chen, Qian Zhang, Shizhen Su, Junhao Yan, Tianxiang Ni   +7 more
doaj   +1 more source

An Analysis of Reproductive Health Issues in Pakistan [PDF]

Population programmes in many developing countries have emphasised on family planning services driven largely by numbers and demographic targets. With the advent of the International Conference on Population and Development (ICPD) in 1994, it has been ...
Durr-E-Nayab, Naushin Mahmood
core  

Youth Reproductive Health in Nepal: Is Participation the Answer? [PDF]

, 2004
Discusses the processes and results of a multi-year research study by ICRW, EngenderHealth, and Nepali partners, which tested the effectiveness of the participatory approach in defining and addressing the reproductive health concerns of ...
Anju Malhotra, Manisha Mehta, Sanyukta Mathur   +2 more
core  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Improving the Reproductive Health of Married and Unmarried Youth in India [PDF]

, 2006
Provides insights and lessons learned from a ten-year multi-partner research program to improve youth reproductive and sexual health in India.
Kathleen Kurz, Kerry MacQuarrie, Rohini Pande, Saranga Jain, Sunayana Walia   +4 more
core  

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Crosstalk between H3K4me3 and oxidative stress is a potential target for the improvement of ART-derived embryos

Nature Communications
With the advent and development of assisted reproductive technology (ART), more and more people affected by infertility have been able to obtain offspring successfully. Nevertheless, various adverse outcomes have been found to be associated with ART, and
Chuanxin Zhang, Hao Tian, Xiaoyu Yin, Xueqi Dong, Ning Wang, Yiwen Zhang, Jiawei Wang, Jinzhu Song, Cheng Li, Zi-Jiang Chen, Boyang Liu, Keliang Wu   +11 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source