Results 121 to 130 of about 8,608,754 (407)

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Health Promotion Model "Extracurricular" Approach of Reproductive Health Among Early Adolescents [PDF]

, 2018
The behavior to maintenance of reproductive organs, and self-adjustment on changes during puberty become its own problems on early adolescence (10-14 years old).
Hastuti, L. (Lidia), Hidayah, H. (Hidayah), Lestari, L. (Lilis), Makmuriana, L. (Lestari), Wuriani, W. (Wuriani)   +4 more
core  

Protecting Reproductive Health and the Environment: Toxics Use Reduction [PDF]

, 1993
Kenneth Geiser
openalex   +2 more sources

Biallelic BRCA2 variants induce premature ovarian insufficiency by impaired meiotic homologous recombination

Communications Biology
The DNA damage response plays a pivotal role in ovarian aging. Breast cancer susceptibility gene 2 (BRCA2), which participates in homologous recombination (HR), is a key regulator of natural menopause. Rare BRCA2 variants have been identified in patients
Xinyi Wu, Qian Zhang, Chang Li, Shuning Zhuang, Hongyuan Liu, Xue Jiao, Shidou Zhao, Yingying Qin, Ting Guo   +8 more
doaj   +1 more source

Reproductive Health in Women with Physical Disability: A Conceptual Framework for the Development of New Patient-Reported Outcome Measures.

Journal of Women's Health, 2020
Background: Barriers in the built environment, enduring stereotypes and biases, and limited disability competency of health care providers compromise access to and quality of reproductive health care for women with physical disabilities.
C. Kalpakjian, Jodi M. Kreschmer, M. Slavin, Pamela A. Kisala, E. Quint, N. Chiaravalloti, N. Jenkins, T. Bushnik, D. Amtmann, D. Tulsky, Roxanne Madrid, R. Parten, Michael Evitts, Carolyn L Grawi   +13 more
semanticscholar   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Need Assessment and Effect of Sex Education on Awareness and Knowledge among Primary School Students in Klaten, Central Java [PDF]

, 2016
BACKGROUND: Lack of knowledge in reproductive health and weak parental control may have undesired impact on children. There appeared the need of sex education and teaching in reproductive health for school children.
Wartoyo, F. X. (Franciscus)
core   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Alcohol Production as an Adaptive Livelihood Strategy for Women Farmers in Tanzania and Its Potential for Unintended Consequences on Women's Reproductive Health. [PDF]

, 2013
Although women occupy a central position in agriculture in many developing countries, they face numerous constraints to achieving their full potential including unequal access to assets and limited decision-making authority.
B Agarwal, BS Feldman, CL Miller, FA Browne, FE Greig, H Ladmadrid-Figueroa, J Kim, JA Rivera, JC Fisher, JL Oyefara, JT Boerma, KL Dunkle, KN Dancause, Lauren J. Ralph, M McCall, M Morris, MF Chersich, MH Watt, Nancy S. Padian, P Gertler, PM Pronyk, PM Pronyk, RK Papas, S Ahmed, Sandra I. McCoy, SC Kalichman, SG Sosa-Rubi, Sten H. Vermund, Wema Wilson   +28 more
core   +3 more sources

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source