Results 121 to 130 of about 391,028 (345)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

open access: yesMolecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy   +9 more
wiley   +1 more source

An Analysis of Reproductive Health Issues in Pakistan [PDF]

open access: yes
Population programmes in many developing countries have emphasised on family planning services driven largely by numbers and demographic targets. With the advent of the International Conference on Population and Development (ICPD) in 1994, it has been ...
Durr-E-Nayab, Naushin Mahmood
core  

Presidential Constitutionalism and Civil Rights [PDF]

open access: yes, 2014
As the judicial and legislative branches have taken a more passive approach to civil rights enforcement, the President’s exercise of independent, extrajudicial constitutional judgment has become increasingly important. Modern U.S.
Landau, Joseph
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

Reproductive Health and the Millennium Development Goals I: The Missing Link [PDF]

open access: yes, 2004
When the General Assembly adopted the Millennium Declaration in 2000 and, a year later, the Millennium Development Goals, an explicit commitment to the reproductive rights of women was nowhere to be ...
Barbara Crossette
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

AWARENESS ABOUT REPRODUCTIVE HEALTH AND RIGHTS AMONG STUDENTS OF A PUBLIC UNIVERSITY IN KARACHI, PAKISTAN: A CROSS SECTIONAL STUDY

open access: yesJournal of the Dow University of Health Sciences, 2012
Objective: To determine the knowledge, attitude and practices of Karachi University students about reproductive health and rights. Design: Cross sectional study Methods: A survey was conducted from February to May 2005 to determine the ...
Waris Qidwai   +3 more
doaj   +2 more sources

Banning Abortion in Cases of Down Syndrome: Important Lessons for Advances in Genetic Diagnosis [PDF]

open access: yes, 2018
In December 2017, Ohio passed into law legislation that prohibited physicians from performing abortions if the pregnant woman’s decision was influenced by her belief that the fetus has Down syndrome.
Gostin, Lawrence O., Reingold, Rebecca
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

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