Results 71 to 80 of about 163,050 (289)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Effect of Vitamin D Supplementation on Intracytoplasmic Sperm Injection Outcomes: A Randomized Double-Blind Placebo-Controlled Trial [PDF]

International Journal of Fertility and Sterility, 2019
Background Despite numerous studies indicating an imperative role for reproduction, however, the role of Vitamin D supplementation on outcomes of assisted reproductive techniques remains controversial.
Sara Abedi, Mahboubeh Taebi
doaj   +1 more source

Customizing Conception: A Survey of Preimplantation Genetic Diagnosis and the Resulting Social, Ethical, and Legal Dilemmas [PDF]

, 2002
One in six American couples experience difficulties conceiving a child. With fertility rates at an all time low, the business of treating infertility is booming.
Roberts, Jason Christopher
core   +1 more source

Regulating Reprogenetics: Strategic Sacralisation and Semantic Message [PDF]

, 2007
This paper forms part of the feminist critique of the regulatory consequences of biomedicine's systematic exclusion of the role of women's bodies in the development ofreprogenetic technologies.
Mackenzie, Robin
core   +1 more source

Cryopreservation of equine oocytes: looking into the crystal ball [PDF]

, 2020
In vitro embryo production has evolved rapidly in the horse over the past decade, but blastocyst rates from vitrified equine oocytes remain quite poor and further research is needed to warrant application.
Angel Velez, Daniel, De Coster, Tine, Smits, Katrien, Van Soom, Ann, Woelders, Henri   +4 more
core   +2 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Working Motivation Sources and Related Factors of Embryologists

Fertility & Reproduction
Introduction: As the need for assisted reproductive technologies (ART) continues to grow, the workload for embryologists has significantly increased in recent years.
Nga T. T. Do, Diem T. N. Nguyen, Duy L. Nguyen, Bao G. Huynh, Tuong M. Ho   +4 more
doaj   +1 more source

Outcome of twin pregnancies conceived after assisted reproductive techniques

Journal of Human Reproductive Sciences, 2008
Context : There is a continuous controversy regarding the obstetric perinatal outcome of twin pregnancies conceived after assisted reproductive techniques (ART). There is an ongoing discussion whether theses parameters may show poorer results as compared
A Baxi, M Kaushal
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Advanced sperm selection techniques for assisted reproduction [PDF]

Cochrane Database of Systematic Reviews, 2013
Assisted reproductive technologies (ART) including in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI), combine gametes to enhance the probability of fertilisation and pregnancy. Advanced sperm selection techniques are increasingly employed in ART, most commonly in cycles utilising ICSI.
Lepine, Sam, McDowell, Simon, Searle, Leigh M., Kroon, Ben, Glujovsky, Demián, Yazdani, Anusch   +5 more
openaire   +6 more sources