Results 61 to 70 of about 475,651 (353)

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

The meaning of repeated assisted reproductive technologies failures experienced of older infertile women

Frontiers in Reproductive Health
IntroductionThe trend of older pregnant women and infertile women in South Korea, who are influencing the low birth rate, is on the rise. Older infertile women earnestly hoped for pregnancy and persisted in undergoing assisted reproductive technology ...
Hyun Jung Oh, Gisoo Shin
doaj   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Assisted reproductive technology in the USA: is more regulation needed? [PDF]

, 2014
The regulation of assisted reproductive technologies is a contested area. Some jurisdictions, such as the UK and a number of Australian states, have comprehensive regulation of most aspects of assisted reproductive technologies; others, such as the USA ...
Adamson, Allen, ASRM, ASRM, ASRM, ASRM and SART Practice Committee, ASRM Ethics Committee, ASRM Office of Public Affairs, Basu, Cahn, Cahn, Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, Chambers, Cohen, Conrad, D'Orazio, De Neubourg, England and Wales High Court, Eric Blyth, Food and Drug Administration, Gleicher, Gleicher, Gürtin, Hamilton, Heled, HFEA, HFEA, HFEA, HFEA, HFEA, HFEA, Isley, Johnson, Jones, Jungheim, Kalfoglou, Keel, Kushnir, Lewis, Lim, Lucy Frith, Macaldowie, Martin, Ory, Rebar, Sawyer, Sims, Spar, Sunderam, Sylvester, The National Conference of State Legislatures, The National Conference of State Legislatures, The National Conference of State Legislatures, The National Conference of State Legislatures, Tobin, Washington   +60 more
core   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Mitochondrial DNA transfer: some reflections from the United Kingdom [PDF]

, 2015
Recent medical advances and subsequent law reform in the United Kingdom have reignited debate about the ethics of mitochondrial DNA donation and transfer.
McLean, Sheila A.
core  

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Perfil de puérperas submetidas a métodos de reprodução assistida [Profile of postpartum women submitted to assisted reproduction methods] [Perfil de puérperas sometidas a métodos de reproducción asistida]

Revista Enfermagem UERJ, 2012
Estudo cujo objetivo foi discutir o perfil de mulheres submetidas a métodos de reprodução assistida em hospital privado do Município de São Paulo, em 2009. Pesquisa quantitativa, descritiva, exploratória, transversal, de nível I.
Alexandra Celento Vasconcellos da Silva, Maria Mercedes Fernandes Samperiz, Andréa Gomes da Costa Mohallem, Octavio Muniz da Costa Vargens   +3 more
doaj  

Customizing Conception: A Survey of Preimplantation Genetic Diagnosis and the Resulting Social, Ethical, and Legal Dilemmas [PDF]

, 2002
One in six American couples experience difficulties conceiving a child. With fertility rates at an all time low, the business of treating infertility is booming.
Roberts, Jason Christopher
core   +1 more source