Results 91 to 100 of about 1,385,080 (304)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

REPRODUCTIVE TRAITS SELECTION IN NELORE BEEF CATTLE

Ciência e Agrotecnologia, 2015
Genetic breeding programs of beef cattle in Brazil are including new features, mainly related to reproductive efficiency.Thus, it is necessary to study the effectiveness of selection and quantify genetic gain for these traits in herds.
Heverton Luis Moreira, Marcos Eli Buzanskas, Danisio Prado Munari, Érika Breda Canova, Raysildo Barbosa Lôbo, Claudia Cristina Paro de Paz   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Genetic relationships between calving interval and body condition score conditional on milk yield [PDF]

, 2002
Body condition score (BCS) is a useful tool in assessing the energy status of dairy cattle. Previous research has shown that it is heritable and genetically correlated to reproductive performance.
Coffey, M.P., Pryce, J.E., Brotherstone, S.H., Woolliams, John   +3 more
core  

Evaluation of body condition score measured throughout lactation as an indicator of fertility in dairy cattle [PDF]

, 2004
Body condition score (BCS) records of primiparous Holstein cows were analyzed both as a single measure per animal and as repeated measures per sire of cow.
Banos, G, Coffey, MP, Brotherstone, S, Banos, G; id_orcid   +3 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Sexual selection on song and cuticular hydrocarbons in two distinct populations of Drosophila montana [PDF]

, 2011
Sexual selection has the potential to contribute to population divergence and speciation. Most studies of sexual selection in Drosophila have concentrated on a single signaling modality, usually either courtship song or cuticular hydrocarbons (CHCs ...
Butlin, Roger K., Veltsos, P., Anneli Hoikkala, Ritchie, M.G., Veltsos, Paris, Wicker-Thomas, Claude, Ritchie, Michael Gordon, Wicker-Thomas, C., Roger K. Butlin, Ritchie, Michael G., Hoikkala, Anneli, Michael G. Ritchie, Ritchie, Michael, Butlin, R.K., Claude Wicker-Thomas, Paris Veltsos, Butlin, Roger, Hoikkala, A.   +17 more
core   +1 more source

Characterizing differences in the time to onset of puberty and reproductive performance between East Friesian and Corriedale ewe lambs [PDF]

Revista Brasileira de Zootecnia
The objective of the study was to characterize differences in the time to onset of puberty and reproductive variables between East Friesian and Corriedale ewe lambs in an extensive pastoral system. The study was carried out for two consecutive years, and
Karina Neimaur, Fernando Perdigón, Florencia Negrín, Luis Cal-Pereyra, Maria Cecilia Capucho, Mauro Minteguiaga, Roberto Kremer   +6 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source