Results 91 to 100 of about 288,397 (260)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Reprogramming to Pluripotency Using Small Molecule Compounds [PDF]

, 2015
The generation of induced pluripotent stem cells (iPSCs) through the use of small molecule compounds has evolved as a potential cellular reprogramming strategy.
Greenberg, Brittany E., Brittany Greenberg   +1 more
core   +1 more source

Conservation of Methylation Reprogramming in Mammalian Development: Aberrant Reprogramming in Cloned Embryos

, 2001
CONSERVATION OF METHYLATION REPROGRAMMING IN MAMMALIAN DEVELOPMENT: ABERRANT REPROGRAMMING IN CLONED EMBRYOS Conservation of Methylation Reprogramming in Mammalian Development: Aberrant Reprogramming in Cloned Embryos (98) (-
Dean, Wendy Fatima Santos Miodrag Stojkovic Valeri Zakhartchenko Jorn Walter Eckhard Wolf Wolf Reik
core   +1 more source

Recent development on synthetic biological devices treating bladder cancer

Synthetic and Systems Biotechnology, 2016
Synthetic biology is an emerging field focusing on engineering genetic devices and biomolecular systems for a variety of applications from basic biology to biotechnology and medicine.
Zhicong Chen, Anbang He, Yuchen Liu, Weiren Huang, Zhiming Cai   +4 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Phases of reprogramming

, 2014
Despite advances in the field of somatic cell reprogramming, an understanding and exploration of the underlying mechanisms governing this process are only recently emerging.
Polo, J.M., David, L.
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Visualizing and analyzing global knowledge maps and emerging research trends in tumor-derived exosomes using CiteSpace

Discover Oncology
Objective Tumor-derived exosomes testing can be effective in diagnosing disease and assisting in the treatment of disease. Our study utilizes bibliometric analysis to identify research hotspots related to tumor-derived exosomes, predict emerging research
Ruijun Guo, Jiajun Xu, Chunxia Li, Chune Mo, Minglin Ou   +4 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Reprogramming efficiency of rat somatic cells.

, 2012
(A) Reprogramming efficiency of rat fibroblasts (REF, r1wk fb and rAdult fb) by three reprogramming factors (Oct4, Klf4 and Sox2) (left) and by four reprogramming factors (Oct4, Klf4, Sox2 and c-Myc) (right).
Akihide Kamiya (150409), Mami Kawarai (150414), Tomonari Hayama (150423), Hideki Masaki (150438), Sanae Hamanaka (150406), Youn-Su Lee (150429), Toshihiro Kobayashi (150445), Hideyuki Sato (76321), Tomoyuki Yamaguchi (150399), Motohito Okabe (150412), Satoshi Yamazaki (150450), Hiromitsu Nakauchi (150454), Ayumi Umino (150420), Megumi Kato-Itoh (150434), Yukiko Wakiyama (150417)   +14 more
core   +1 more source