Results 101 to 110 of about 205,281 (308)

Corrigendum: Deepening the understanding of CNVs on chromosome 15q11–13 by using hiPSCs: An overview

Frontiers in Cell and Developmental Biology, 2023
Angela Maria Giada Giovenale, Angela Maria Giada Giovenale, Giorgia Ruotolo, Giorgia Ruotolo, Amata Amy Soriano, Elisa Maria Turco, Giovannina Rotundo, Alessia Casamassa, Angela D’Anzi, Angelo Luigi Vescovi, Angelo Luigi Vescovi, Jessica Rosati   +11 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Regenerative Medicine for the Aging Brain [PDF]

, 2014
In the central nervous system, cholinergic and dopaminergic (DA) neurons are among the cells most susceptible to the deleterious effects of age. Thus, the basal forebrain cholinergic system is known to undergo moderate neurodegenerative changes during ...
Goya, Rodolfo Gustavo, Hereñú, Claudia Beatriz, López León, Micaela, Reggiani, Paula Cecilia   +3 more
core   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Epigenetic Dynamics in Reprogramming to Dopaminergic Neurons for Parkinson's Disease

Advanced Science
Direct lineage reprogramming into dopaminergic (DA) neurons holds great promise for the more effective production of DA neurons, offering potential therapeutic benefits for conditions such as Parkinson's disease.
Byounggook Cho, Junyeop Kim, Sumin Kim, Saemin An, Yerim Hwang, Yunkyung Kim, Daeyeol Kwon, Jongpil Kim   +7 more
doaj   +1 more source

Inhibition of Polo-like Kinase 1 Prevents the Male Pronuclear Formation Via Alpha-tubulin Recruiting in In Vivo-fertilized Murine Embryos

Journal of Animal Reproduction and Biotechnology, 2018
Polo-like kinase 1 (Plk1) has been known to be a critical element in cell division including centrosome maturation, cytokinesis and spindle formation in somatic, cancer, and mammalian embryonic cells.
Jeonghyeon Moon, Sangho Roh
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Relative Stability of Network States in Boolean Network Models of Gene Regulation in Development

, 2015
Progress in cell type reprogramming has revived the interest in Waddington's concept of the epigenetic landscape. Recently researchers developed the quasi-potential theory to represent the Waddington's landscape.
d'Hèrouël, Aymeric Fouquier, Huang, Sui, Price, Nathan D., Samal, Areejit, Zhou, Joseph Xu   +4 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Reprogramming Restores Vision in Mice by Changing DNA Methylation

, 2021
Jiali Shi, Shanshan Sun, Yongjie Wang, Zhihui Huang   +3 more
openalex   +2 more sources