Results 101 to 110 of about 288,397 (260)
Genetic Reprogramming Following Nuclear Transplantation in Amphibia
, 1999 GENETIC REPROGRAMMING FOLLOWING NUCLEAR TRANSPLANTATION IN AMPHIBIA Genetic Reprogramming Following Nuclear Transplantation in Amphibia (10) (-
Gurdon, J.B.
core +1 more source
Diversity Control in Early Transcribed ROS/RNSbalancing Genes: A Common Mechanism for Healthy Resilience? [PDF]
Innovations in Digital Health, Diagnostics, and Biomarkers, 2022 Birgit Arnholdt-Schmitt +2 more
doaj +1 more source
Cancer & Metabolism, 2019 Background Increased flux through both glycolytic and oxidative metabolic pathways is a hallmark of breast cancer cells and is critical for their growth and survival.
Sheree D. Martin, Sean L. McGee
doaj +1 more source
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
Cancer cell reprogramming conditions.
, 2015 Cells positive for the live stain alkaline phosphatase (AP) cells were counted as indicators of cancer reprogramming. HT29 cells were transfected with miRs as indicated and grown in culture under several conditions (culture medium, MEF feeder cells, and ...
Hiroaki Nagano (282467) +18 more
core +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Transcription factors used for hepatic reprogramming.
, 2014 11TF includes all genes.*Included in 6TF.Sufficient for hepatic reprogramming when combined with HNF1A.Necessary for hepatic reprogramming.
Kamen P. Simeonov (588591) +1 more
core +1 more source
Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang +4 more
wiley +1 more source