Results 81 to 90 of about 288,397 (260)

Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells [PDF]

, 2014
The anti-diabetic drug metformin regulates T-cell responses to immune activation and is proposed to function by regulating the energy-stress-sensing adenosine-monophosphate-activated protein kinase (AMPK).
Benoit Viollet, David K. Finlay, Doreen A. Cantrell, Finlay David K., Viollet, Benoit, Marc Foretz, Cantrell, Doreen A., Viollet Benoit, FINLAY, DAVID, Marouan Zarrouk, Zarrouk, Marouan, David K Finlay, Doreen A Cantrell, Zarrouk Marouan, Foretz, Marc, Foretz Marc, Cantrell Doreen A., Finlay, David K.   +17 more
core   +1 more source

Amphiregulin mediates non-cell-autonomous effect of senescence on reprogramming

, 2022
International audienceCellular senescence is an irreversible growth arrest with a dynamic secretome, termed the senescence-associatedsecretory phenotype (SASP).
Gianetto, Quentin Giai, Li, Han, Chen, Cheng, Matondo, Mariette, Douché, Thibaut, Chantrel, Jérémy, Chiche, Aurélie, von Joest, Mathieu, Mathieu von Joest, Aurélie Chiche, Han Li, Mariette Matondo, Thibaut Douché, Cheng Chen, Quentin Giai Gianetto, Jeremy Chantrel   +15 more
core   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Sequential Reprogramming of Boolean Networks Made Practical [PDF]

, 2019
Best paper awardInternational audienceWe address the sequential reprogramming of gene regulatory networks modelled as Boolean networks. We develop an attractor-based sequential reprogramming method to compute all sequential reprogramming paths from a ...
Stefan Haar, Pang, Jun, Su, Cui, Haar, Stefan, Loïc Paulevé, Mandon, Hugues, Jun Pang, Hugues Mandon, Paulevé, Loïc, Cui Su   +9 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Delivery Systems in Neuronal Direct Cell Reprogramming

Neuronal direct cell reprogramming approach allows direct conversion of somatic cells into neurons via forced expression of neuronal cell-lineage transcription factors (TFs).
Del Piano, Filomena, Caiazzo, Massimiliano, Cappellini, Sara, Redi, Giulia, den Breejen, Anne, Paladino, Martina, Fens, Marcel H. A. M.   +6 more
core   +1 more source

Deconstructing age reprogramming

, 2019
It has been proposed that age reprogramming enables old cells to be rejuvenated without passage through an embryonic stage (Singh and Zacouto in J. Biosci. 35 315-319, 2010). As such, age reprogramming stands apart from the induced pluripotent stem (iPS)
Newman, A.G., Laktionov, P.P., Singh, P.B.   +2 more
core   +1 more source

[Reprogramming equals gambling?]. [PDF]

, 2013
International audienceWhile somatic cell reprogramming is now part of our text books, we ignore most of the mechanisms governing this cellular transformation.
John De Vos, Laurent David, David, Laurent, de Vos, John   +3 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Transcriptome Analyses in Adult Olive Trees Indicate Acetaldehyde Release and Cyanide-Mediated Respiration Traits as Critical for Tolerance against Xylella fastidiosa and Suggest AOX Gene Family as Marker for Multiple-Resilience

Pathogens
Xylella fastidiosa (Xf) is a global bacterial threat for a diversity of plants, including olive trees. However, current understanding of host responses upon Xf-infection is limited to allow early disease prediction, diagnosis, and sustainable strategies ...
Birgit Arnholdt-Schmitt, Debabrata Sircar, Shahid Aziz, Thais Andrade Germano, Karine Leitão Lima Thiers, Carlos Noceda, Revuru Bharadwaj, Gunasekaran Mohanapriya, José Hélio Costa   +8 more
doaj   +1 more source