Results 41 to 50 of about 2,823,354 (291)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Lithuania on the way to energy independence: an experience or a lesson? [PDF]
Baltic Region, 2010 The article considers the steps taken by Lithuania towards gaining energy independence in the interbellum and the Soviet periods. The author analyses the peculiarities of the republic's energy policy after achieving independence in the early 1990s and ...
Kretinin Gennady
doaj +1 more source
Networking in the Republic of Letters: Magliabechi and the Dutch Republic
The Journal of Interdisciplinary History, 2022 Abstract The brokers who forge networks have exclusive access to diverse and innovative information. Hence, many histories of the Republic of Letters (1500–1800) stress the importance of brokers for the circulation and development of new ideas.
openaire +2 more sources
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
European Papers(Series Information) European Papers - A Journal on Law and Integration, 2024 9(1), 461-462 | Editorial | (Abstract) Europe is changing its political genome. The ontologically political diversity between the Union and its Member States seems to wane. The
Enzo Cannizzaro
doaj +1 more source
ACROSS TWO SEAS: COOPERATION AMONG SOCIAL SCIENCE SCHOLARS OF POLAND AND KAZAKHSTAN
Vestnik MGIMO-Universiteta, 2018 A collection of research papers by Polish, Kazakh and Lithuanian authors dedicated to the formation and development of modern Kazakhstan was published in 2016.
S. A. Sklyarov
doaj +1 more source
The Anthropocene and the republic [PDF]
Critical Review of International Social and Political Philosophy, 2019 The Anthropocene, understood from the perspective of the creators of Earth System Science and IPCC, calls for global governance, which tends to be understood as an epistocratic, technocratic affair...
openaire +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source