Results 51 to 60 of about 57,405 (292)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Using expert-elicitation to deliver biodiversity monitoring priorities on a Mediterranean island.

PLoS ONE, 2022
Biodiversity monitoring plays an essential role in tracking changes in ecosystems, species distributions and abundances across the globe. Data collected through both structured and unstructured biodiversity recording can inform conservation measures ...
J Peyton, M Hadjistylli, I Tziortzis, E Erotokritou, M Demetriou, Y Samuel, V Anastasi, G Fyttis, L Hadjioannou, C Ieronymidou, N Kassinis, P Kleitou, D Kletou, A Mandoulaki, N Michailidis, A Papatheodoulou, G Payiattas, D Sparrow, R Sparrow, K Turvey, E Tzirkalli, A I Varnava, O L Pescott   +22 more
doaj   +1 more source

Collaborative mint map tool to facilitate requirement elicitation [PDF]

, 2011
Requirements elicitation is a crucial task in any software development process.It is notable as a major contributor to the project failure.To minimize and subsequently improve the process, folding Mind Map concept in the elicitation process and ...
Abdul Hamid, Nazatul Naquiah Ahba, Atan, Mislina, Jaafar, Juliana   +2 more
core  

A framework for security requirements engineering [PDF]

, 2006
This paper presents a framework for security requirements elicitation and analysis, based upon the construction of a context for the system and satisfaction arguments for the security of the system. One starts with enumeration of security goals based on
Haley, Charles B., Laney, Robin, Moffett, Jonathan D., Nuseibeh, Bashar   +3 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Ontology Driven Requirement Specification

JISR on Computing, 2017
Requirement engineering (RE) process is an important step of software development lifecycle and it includes a variety of activities starting with requirement elicitation to requirement documentation. This form of engineering is the backbone of a quality
Adeel Ahmed, Fabeha Maniar
doaj   +1 more source

A Necessity-Based Method for Product Requirement Elicitation and Classification [PDF]

, 2016
A new necessity-based method for the elicitation and classification of requirements in the early phases of the product design process is presented. The purpose is to guide a design engineer through the process of requirement elicitation so as to compile ...
Bojan Dolšak, Špela Brglez
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Using Dissemination and Implementation Strategies to Evaluate Requirement Elicitation Guidelines: A Case Study in a Bed Management System

IEEE Access, 2020
Clinical software is a fundamental tool for supporting healthcare systems because it improves the quality of patient care and automatizes the most frequently performed clinical tasks. Nevertheless, since health systems include various components, such as
Gaston Marquez, Carla Taramasco
doaj   +1 more source

What If People Learn Requirements Over Time? A Rough Introduction to Requirements Economics [PDF]

, 2017
The overall objective of Requirements Engineering is to specify, in a systematic way, a system that satisfies the expectations of its stakeholders.
Burnay, Corentin, Jureta, Ivan
core   +1 more source