Results 71 to 80 of about 1,511,705 (293)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Integrated engineering environments for large complex products [PDF]

, 2002
An introduction is given to the Engineering Design Centre at the University of Newcastle upon Tyne, along with a brief explanation of the main focus towards large made-to-order products.
A.H.B. Duffy, Andreasen, M.M., Eppinger, S.D., Finin, T., G. Coates, I. Ritchey, Karandikar, H.M., Matta, N., McAlinden, L.P., McCord, K.R., Object Management Group (OMG), Owen, J., R.I. Whitfield, Steward, D.V., Tan, G.W., Tidwell, D., Todd, D.S., Tomiyama, T., W. Hills, Whitfield, R.I., Whitfield, R.I., Winner, R.I.   +21 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Machine Learning Evaluation of the Requirement Engineering Process Models for Cloud Computing and Security Issues

Applied Sciences, 2020
In the requirement engineering phase, the team members work to get the user requirements, comprehend them and specify them for the next process. There are many models for the requirement engineering phase.
Muhammad Asgher Nadeem, Scott Uk-Jin Lee
doaj   +1 more source

Understanding Social and Environmental Requirements in China [PDF]

, 2009
Rapid changes in the social and technical environment bring about many new challenges to system requirements engineering, amongst which out-sourcing or off-shoring of certain design tasks to countries with more human resources and broader markets becomes
Liu, Lin
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Annotation of Software Requirements Specification (SRS), Extractions of Nonfunctional Requirements, and Measurement of Their Tradeoff

IEEE Access, 2019
Software requirement artifacts such as manuals request for proposals, and software requirements specification (SRS) are commonly focused on functional requirements.
Muhammad Asif, Ishfaq Ali, Muhamad Sheraz Arshed Malik, Muhammad Hasanain Chaudary, Shahzadi Tayyaba, Muhammad Tariq Mahmood   +5 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

ESTABLISHING REQUIREMENT IN TEACHING NEW AND RENEWABLE ENERGY

Simetris: Jurnal Teknik Mesin, Elektro dan Ilmu Komputer, 2019
The distinctive shortage in the availability of skilled labor in new and renewable energy sector becomes the issue that has been prevented this country in achieving the national energy mix in 2015 and 2050.
Meredita Susanty, Ariana Yunita, Erwin Setiawan   +2 more
doaj   +1 more source

Designing Requirements Engineering Research [PDF]

2007 Fifth International Workshop on Comparative Evaluation in Requirements Engineering, 2007
Engineering sciences study different topics than natural sciences, and utility is an essential factor in choosing engineering research problems. But despite these differences, research methods for the engineering sciences are no different than research methods for any other kind of science. At most there is a difference in emphasis.
Wieringa, Roelf J., Heerkens, Johannes M.G.   +1 more
openaire   +3 more sources